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Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism
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Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism
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Journal Article
Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism
2019
Overview
Mental health disorders are manifested in families, yet cannot be fully explained by classical Mendelian genetics. Changes in gene expression via epigenetics present a plausible mechanism. Anxiety often leads to avoidant behaviors which upon repetition may become habitual, maladaptive and resistant to extinction as observed in obsessive compulsive disorders (OCD). Psychophysical models of OCD propose that anxiety (amygdala) and habits (dorsolateral striatum, DLS) may be causally linked. The amygdala activates spiny projection neurons in the DLS. Repetitive amygdala terminal stimulation in the DLS elicits long term OCD-like behavior in mice associated with circuitry changes and gene methylation-mediated decrease in the activity of protein phosphatase 1 (PP1). Treatment of OCD-like grooming behavior in Slitrk5, SAPAP3, and laser-stimulated mice with one dose of RG108 (DNA methyltransferase inhibitor), lead to marked symptom improvement lasting for at least one week as well as complete reversal of anomalous changes in circuitry and PP1 gene methylation.
Publisher
Nature Publishing Group,Nature Publishing Group UK
Subject
/ Animals
/ Anxiety
/ Compulsive Behavior - drug therapy
/ Compulsive Behavior - genetics
/ Compulsive Behavior - metabolism
/ Compulsive Behavior - pathology
/ DNA Methylation - drug effects
/ Epigenesis, Genetic - drug effects
/ Female
/ Genetics
/ Grooming
/ Humans
/ Male
/ Mice
/ Obsessive compulsive disorder
/ Obsessive-Compulsive Disorder - drug therapy
/ Obsessive-Compulsive Disorder - genetics
/ Obsessive-Compulsive Disorder - metabolism
/ Obsessive-Compulsive Disorder - pathology
