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Asking the Right Questions in Alzheimer's Research
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Asking the Right Questions in Alzheimer's Research
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Journal Article
Asking the Right Questions in Alzheimer's Research
2018
Overview
Forty years into a full-on effort to defeat Alzheimer's disease as a major cause of cognitive decline and death-- indeed, it is the sixth leading cause of death in the US, afflicting nearly six million people and wreaking enormous emotional and financial tolls on patients and families--this is where things stand: we have no treatments, and though efforts to improve early-stage diagnosis have had some success, their main impact is to inject enormous new uncertainties and anxieties into a patient's view of the future and sense of self. Once a field commits to a particular hypothesis, the research resources--funding, experimental models, and training--all get in line. Alternative hypotheses struggle to survive. An important consequence of hitching the field of ALZ research to the amyloid hypothesis is the dependence of researchers on established experimental animal models that have little or nothing to say about human neurodegeneration.
