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Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes in Drosophila
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Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes in Drosophila
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Journal Article
Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes in Drosophila
2025
Overview
The interplay between diet and the gut microbiome is fundamental to shaping host physiology and behavior; however, their interactions remain poorly understood. Most studies treat diet as a single-dimensional variable (e.g., high-fat or high-sugar), overlooking the complexity of nutrient balance and density. This oversimplification neglects how diet and microbes function as an integrated system. This study addresses this gap by testing 120 different nutrient-microbiome combinations in Drosophila melanogaster , systematically varying yeast and carbohydrate levels and microbiome configurations. Our results show that dietary nutrient composition drives body protein and fat storage, whereas the microbiome plays a notable role in glucose metabolism and buffers against excess fat accumulation. Microbial effects on reproduction, locomotion, and sleep depend on nutrient composition, and our model reveals specific diet-microbiome patterns driving these outcomes. By treating diet as a dynamic, multidimensional factor, we provide a novel, ecologically relevant framework for understanding how diet and microbiome shape host.
Publisher
American Society for Microbiology
Subject
/ Animal Models of Host-Microbiome Interactions
/ Animals
/ Behavior
/ Diet
/ Drosophila melanogaster - microbiology
/ Drosophila melanogaster - physiology
/ Eggs
/ Female
/ Females
/ Gastrointestinal Microbiome - physiology
/ Host-Microbiome Interactions
/ Insects
/ Male
/ Microbial Ecology and Evolution
/ Microbiome and Host Metabolism
/ Microbiota-Host Interactions
/ Proteins
/ Ratios
/ Sleep
/ Sucrose
/ Symbiosis and Host Interactions
/ Yeast
