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Diversity and spillover risk of swine acute diarrhea syndrome and related coronaviruses in China and Southeast Asia
Diversity and spillover risk of swine acute diarrhea syndrome and related coronaviruses in China and Southeast Asia
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Diversity and spillover risk of swine acute diarrhea syndrome and related coronaviruses in China and Southeast Asia
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Diversity and spillover risk of swine acute diarrhea syndrome and related coronaviruses in China and Southeast Asia
Diversity and spillover risk of swine acute diarrhea syndrome and related coronaviruses in China and Southeast Asia

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Diversity and spillover risk of swine acute diarrhea syndrome and related coronaviruses in China and Southeast Asia
Diversity and spillover risk of swine acute diarrhea syndrome and related coronaviruses in China and Southeast Asia
Journal Article

Diversity and spillover risk of swine acute diarrhea syndrome and related coronaviruses in China and Southeast Asia

2025
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Overview
Bats are the reservoir or ancestral hosts of important emerging coronaviruses affecting people (e.g., SARS-CoV and SARS-CoV-2) and livestock (e.g., PEDV, SADS-CoV). Here, we analyzed 523 genetic sequences of SADS-CoV that caused large-scale die-offs of pigs in China, which is known to be able to infect human cells and related HKU2-CoVs. We used this information to identify the horseshoe bat Rhinolophus affinis as the likely spillover host for the outbreak in pigs, and identified the bat species within which these viruses evolved. We then modeled the distribution of these host species and their overlap with dense human and pig populations to identify the regions where surveillance programs can help identify spillover events and prevent future outbreaks.