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Effective treatment of advanced Oropouche virus, Rift Valley fever virus, and Dabie bandavirus infections with 4'-fluorouridine
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Effective treatment of advanced Oropouche virus, Rift Valley fever virus, and Dabie bandavirus infections with 4'-fluorouridine
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Effective treatment of advanced Oropouche virus, Rift Valley fever virus, and Dabie bandavirus infections with 4'-fluorouridine
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Journal Article
Effective treatment of advanced Oropouche virus, Rift Valley fever virus, and Dabie bandavirus infections with 4'-fluorouridine
2025
Overview
Re-emerging and emerging viral diseases, for which no approved vaccines or therapeutics exist, pose a significant public health threat in affected areas of the world. Antiviral drugs that are broadly active against multiple pathogenic viruses are much needed. Our findings demonstrating robust protection conferred by treatment with 4′-fluorouridine (4′-FlU) in viral infection models for Oropouche fever, Rift Valley fever, and severe fever with thrombocytopenia syndrome support the continuing development of this promising broad-spectrum antiviral drug candidate for the treatment of these notable viral diseases.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Animals
/ Antiviral Agents - administration & dosage
/ Antiviral Agents - pharmacology
/ Antiviral Agents - therapeutic use
/ Arboviral Infections (e.g., Dengue, Zika, Chikungunya)
/ Bunyaviridae Infections - drug therapy
/ Bunyaviridae Infections - virology
/ Clinical Microbiology and Infectious Diseases
/ Epidemiology and Geographic Distribution
/ Female
/ Fever
/ Genomes
/ Humans
/ Major Zoonotic Virus Families
/ Mice
/ Orthobunyavirus - drug effects
/ Proteins
/ Rift Valley fever virus - drug effects
/ Severe acute respiratory syndrome coronavirus 2
/ Vaccines
/ Virology
/ Viruses
