Journal Article

Impact of androgenic anabolic steroid use on cardiovascular and mental health in Danish recreational athletes: protocol for a nationwide cross-sectional cohort study as a part of the Fitness Doping in Denmark (FIDO-DK) study

Lehmann Christensen, Louise, Diederichsen, Axel, Kistorp, Caroline Michaela, Lindholt, Jes Sanddal, Glintborg, Dorte, Frystyk, Jan, Andersen, Marianne, Buhl, Laust Frisenberg

2024

Overview

IntroductionThe use of androgenic anabolic steroids (AASs) among recreational athletes is steadily increasing. However, knowledge regarding the potentially harmful effects of AAS primarily originates from case reports and small observational studies. This large-scale study aims to investigate the impact of AAS use on vascular plaque formation, preclinical coronary disease, cardiac function, circulating cardiovascular risk markers, quality of life (QoL) and mental health in a broad population of illicit AAS users.Methods and analysesA nationwide cross-sectional cohort study including a diverse population of men and women aged ≥18 years, with current or previous illicit AAS use for at least 3 months. Conducted at Odense University Hospital, Denmark, the study comprises two parts. In part A (the pilot study), 120 recreational athletes with an AAS history will be compared with a sex-matched and age-matched control population of 60 recreational athletes with no previous AAS use. Cardiovascular outcomes include examination of non-calcified coronary plaque volume and calcium score using coronary CT angiography, myocardial structure and function via echocardiography, and assessing carotid and femoral artery plaques using ultrasonography. Retinal microvascular status is evaluated through fundus photography. Cardiovascular risk markers are measured in blood. Mental health outcomes include health-related QoL, interpersonal difficulties, body image concerns, aggression dimensions, anxiety symptoms, depressive severity and cognitive function assessed through validated questionnaires. The findings of our comprehensive study will be used to compose a less intensive investigatory cohort study of cardiovascular and mental health (part B) involving a larger group of recreational athletes with a history of illicit AAS use.Ethics and disseminationThe study received approval from the Regional Committee on Health Research Ethics for Southern Denmark (S-20210078) and the Danish Data Protection Agency (21/28259). All participants will provide signed informed consent. Research outcomes will be disseminated through peer-reviewed journals and scientific conferences.Trial registration number NCT05178537.

• Publisher: British Medical Journal Publishing Group,BMJ Publishing Group LTD,BMJ Publishing Group
• Subject: Adult / Anabolic Agents - adverse effects / Anabolic Androgenic Steroids / Anabolic steroids / Androgens - adverse effects / Atherosclerosis / Athletes - psychology / Cardiology / Cardiomyopathy / Cardiovascular Diseases - epidemiology / Cardiovascular imaging / Cardiovascular medicine / Cohort analysis / Cohort Studies / Correspondence / Cross-Sectional Studies / Denmark - epidemiology / Disease / Doping in Sports / Drug dosages / Female / Females / General endocrinology / Heart Disease Risk Factors / Humans / Male / Males / Mental depression / Mental Health / Mortality / Physical fitness / Pilot Projects / Population / Quality of Life / Questionnaires / Recreation / Research Design / Self report / Sex steroids & HRT / Social networks / Testosterone Congeners - adverse effects / Ultrasonic imaging