Journal Article

Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV)

Aebi-Popp, K, Rickenbach, M, Stöckle, Marcel, Furrer, H, Hoffmann, M, Schüpbach, J, Trkola, A, Kouyos, RD, Notter, J, Haerry, D, Traytel, Anna, Perreau, M, Klimkait, T, Marzolini, C, Cavassini, M, Kohns, M, Brunner, Anja, Francioli, P, Ledergerber, B, Calmy, A, Siegrist, C-A, Egger, M, Elzi, L, Hösli, I, Pantaleo, G, Capaul, Murezi, Tarr, P, Hösli, Irene, Rauch, A, Kovari, H, Kaiser, L, Böni, J, Ciuffi, A, Weisser, M, Dollenmaier, G, Nemeth, J, Crisinel, PA, Kapfhammer, E, Rudin, C, Bucher, HC, Günthard, HF, Müller, N, Hachfeld, A, Braun, DL, Fehr, J, Martinez de Tejada, B, Paioni, Paolo, Martinez De Tejada, Begona, Keiser, O, Jackson-Perry, D, Abela, I, Battegay, M, Francini, K, Duppenthaler, Andrea, Salazar-Vizcaya, L, Wagner, Noemie, Scherrer, Alexandra, Metzner, KJ, Kind, C, Thanh Lecompte, M, Darling, K, Schmid, P, Stöckle, M, Wandeler, G, Hirsch, HH, Bernasconi, E, Hasse, B, Nicca, D, Fellay, J, Speck, R, Baumann, M, Huber, M, Kottanattu, L, Cheseaux, J-J, Labhardt, N, Aebi-Popp, Karoline, Kottanattu, Lisa, Paioni, P, Rudin, Christoph, Kahlert, CR, Kusejko, K, Duppenthaler, A, Rauch, Andri, Kahlert, Christian R, Fux, CA, Nadal, D, Kusejko, Katharin

2024

Overview

PurposeProspective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general.ParticipantsBetween January 1986 and December 2022, a total of 1446 mother–child pairs were enrolled. During the same period, the study also registered 187 CWH and 521 HIV-exposed but uninfected children (HEU), for whom detailed maternal information was not available. Consequently, the cohort comprises a total of 2154 children.Findings to dateDuring these 37 years, research by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and its international collaborators has strongly influenced the prevention of vertical transmission of HIV (eg, introduction and discontinuation of elective caesarean section, neonatal postexposure prophylaxis and breastfeeding). Contributions have also been made to the management of diagnostics (eg, p24 antigen assay) and the effects of antiretroviral treatment (eg, prematurity, growth) in HEU and CWH.Future plansMost children present within the cohort are now HEU, highlighting the need to investigate other vertically transmitted pathogens such as hepatitis B and C viruses, cytomegalovirus or Treponema pallidum. In addition, analyses are planned on the longitudinal health status of CWH (eg, resistance and prolonged exposure to antiretroviral therapy), on social aspects including stigma in CWH and HEU, and on interventions to further optimise antenatal and postpartum care in WWH.

• Publisher: British Medical Journal Publishing Group,BMJ Publishing Group LTD,BMJ Publishing Group
• Subject: Adult / Age / Antiretroviral drugs / Biobanks / Breast Feeding - statistics & numerical data / Breastfeeding & lactation / Child / Child, Preschool / Childbirth & labor / Children & youth / Cohort analysis / Cohort Profile / Cohort Studies / Consent / Data collection / Disease transmission / Drug therapy / Female / HIV / HIV & AIDS / HIV Infections - epidemiology / HIV Infections - prevention & control / HIV Infections - transmission / Hospitals / Human immunodeficiency virus / Humans / Infant / Infant, Newborn / Infections / Infectious Disease Transmission, Vertical - prevention & control / Laboratories / Male / Mothers / Obstetrics / Pandemics / Pediatrics / Pregnancy / Pregnancy Complications, Infectious - epidemiology / Pregnant Women / Prospective Studies / Public health / Questionnaires / Switzerland - epidemiology / Womens health