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Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
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Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
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Journal Article
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
2002
Overview
We recently isolated a Krüppel-like zinc-finger transcription factor 5 (KLF5; also known as BTEB2 and IKLF), which is markedly induced in activated vascular smooth-muscle cells and fibroblasts. Here we describe our analysis of the
in vivo
function of KLF5 using heterozygous KLF5-knockout mice (
Klf5
+/−
). In response to external stress,
Klf5
+/−
mice showed diminished levels of arterial-wall thickening, angiogenesis, cardiac hypertrophy and interstitial fibrosis. Also, angiotensin II induced expression of KLF5, which in turn activated platelet-derived growth factor-A (PDGF-A) and transforming growth factor-β (TGF-β) expression. In addition, we determined that KLF5 interacted with the retinoic-acid receptor (RAR), that synthetic RAR ligands modulated KLF5 transcriptional activity, and that
in vivo
administration of RAR ligands affected stress responses in the cardiovascular system in a KLF5-dependent manner. KLF5 thus seems to be a key element linking external stress and cardiovascular remodeling.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Angiotensin II - pharmacology
/ Animals
/ Biomedical and Life Sciences
/ Blood Vessels - drug effects
/ Collagen Type IV - metabolism
/ Dibenzazepines - pharmacology
/ Digestive System - anatomy & histology
/ Digestive System Physiological Phenomena
/ Female
/ Heart
/ Humans
/ Kinases
/ Kruppel-Like Transcription Factors
/ Ligands
/ Male
/ Medicine
/ Mice
/ Neovascularization, Physiologic
/ Platelet-Derived Growth Factor - genetics
/ Platelet-Derived Growth Factor - metabolism
/ Rats
/ Recombinant Fusion Proteins - metabolism
/ Retinoids - antagonists & inhibitors
/ Signal Transduction - physiology
/ Trans-Activators - metabolism
/ Ventricular Remodeling - physiology
/ Zinc
