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Functional organization of glomerular maps in the mouse accessory olfactory bulb
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Functional organization of glomerular maps in the mouse accessory olfactory bulb
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Journal Article
Functional organization of glomerular maps in the mouse accessory olfactory bulb
2014
Overview
Unlike that of its main counterpart, the functional organization of the accessory olfactory bulb, important for detecting socially relevant odors, remains to be detailed. Here the authors map out Ca
2+
signals from vomeronasal inputs to the accessory olfactory bulb in response to socially relevant compounds and find a non-chemotopic spatial organization.
The mammalian accessory olfactory system extracts information about species, sex and individual identity from social odors, but its functional organization remains unclear. We imaged presynaptic Ca
2+
signals in vomeronasal inputs to the accessory olfactory bulb (AOB) during peripheral stimulation using light sheet microscopy. Urine- and steroid-responsive glomeruli densely innervated the anterior AOB. Glomerular activity maps for sexually mature female mouse urine overlapped maps for juvenile and/or gonadectomized urine of both sexes, whereas maps for sexually mature male urine were highly distinct. Further spatial analysis revealed a complicated organization involving selective juxtaposition and dispersal of functionally grouped glomerular classes. Glomeruli that were similarly tuned to urines were often closely associated, whereas more disparately tuned glomeruli were selectively dispersed. Maps to a panel of sulfated steroid odorants identified tightly juxtaposed groups that were disparately tuned and dispersed groups that were similarly tuned. These results reveal a modular, nonchemotopic spatial organization in the AOB.
Publisher
Nature Publishing Group US,Nature Publishing Group
