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Pyrimidine Starvation Induced by Adenosine in Fibroblasts and Lymphoid Cells: Role of Adenosine Deaminase
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Pyrimidine Starvation Induced by Adenosine in Fibroblasts and Lymphoid Cells: Role of Adenosine Deaminase
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Journal Article
Pyrimidine Starvation Induced by Adenosine in Fibroblasts and Lymphoid Cells: Role of Adenosine Deaminase
1973
Overview
In the presence of 10$^{-4}$ to 10$^{-5}$ molar adenosine, established cell lines of fibroblastic or lymphoid origin die of pyrimidine starvation. Less than lethal concentrations inhibit cell growth. Over a broad concentration range, the effects of adenosine are prevented by providing a suitable pyrimidine source. We suggest that the recently described immune deficiency disease associated with absence of adenosine deaminase may be the result of pyrimidine starvation induced by adenosine nucleotides in cells of the lymphoid system.
Publisher
American Association for the Advancement of Science
Subject
Adenosine - antagonists & inhibitors
/ Adenosine Diphosphate - biosynthesis
/ Adenosine Triphosphate - biosynthesis
/ Aminohydrolases - metabolism
/ Animals
/ Cytosine Nucleotides - biosynthesis
/ Female
/ Guanine Nucleotides - biosynthesis
/ Guanosine Triphosphate - biosynthesis
/ Humans
/ Lymphoma
/ Mice
/ Pyrimidine Nucleotides - biosynthesis
