Journal Article

Shift from an early protective TH1-type immune response to a late permissive TH2-type response in murine cysticercosis (Taenia crassiceps)

Govezensky, T, Larralde, C, Bojalil, R, Terrazas, L.I

1998

Overview

In early stages of experimental murine cysticercosis caused by Taenia crassiceps, there is a clear but transient Th1-type immune response (characterized by high levels of interleukin [IL]-2, interferon-γ, concanavalin A, and antigen specific response, delayed-type hypersensitivity, and immunoglobulin [Ig]G2a antibodies) that associates with a low rate of parasite reproduction. As time of infection progresses an energic and more permanent Th2-type response follows (characterized by high levels of IL-4, IL-6, IL-10, IgG2b, and IgGl antibodies) that in turn associates with an increment in the rate of parasite reproduction. The sequential activation of Thl-type and Th2-type responses in murine cysticercosis would appear to favor progressively parasite reproduction, explaining the long time residence and the massive parasite intensity reached in chronic infections.

• Publisher: American Society of Parasitologists
• Subject: Animals / Antibodies, Helminth / Antibodies, Helminth - biosynthesis / antibody formation / Antigens / Antigens, Helminth / Antigens, Helminth - immunology / Biological and medical sciences / biosynthesis / Cysticercosis / Cysticercosis - immunology / Cysticercus / Cysticercus - growth & development / Cysticercus - immunology / Cytokines / Cytokines - biosynthesis / cytology / delayed hypersensitivity / Experimental helminthic diseases. Models / experimental infections / Female / growth & development / Helminthic diseases / Hypersensitivity, Delayed / immune response / immunoglobulin G / Immunoglobulin G - biosynthesis / Immunology / Immunophenotyping / Infections / Infectious diseases / Interferon-gamma / Interferon-gamma - biosynthesis / interferons / Interleukin-10 / Interleukin-10 - biosynthesis / Interleukin-2 / Interleukin-2 - biosynthesis / Interleukin-4 / Interleukin-4 - biosynthesis / Interleukin-6 / Interleukin-6 - biosynthesis / interleukins / Lymphocyte Activation / lymphocyte proliferation / Male / Medical sciences / Mice / Mice, Inbred BALB C / Parasites / Parasitic diseases / Parasitism / pathogenesis / reproduction / Sex Characteristics / Spleen / Spleen - cytology / Splenocytes / t helper 1 lymphocytes / t helper 2 lymphocytes / T lymphocytes / Taenia crassiceps / Th1 Cells / Th1 Cells - immunology / Th2 Cells / Th2 Cells - immunology / Transplantation immunology