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Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children

by Mulenga, Veronica , Wills, Genevieve H. , McIlleron, Helen , Choo, Louise , Raichur, Priyanka , Gibb, Diana M. , Turkova, Anna , Chabala, Chishala , Joseph, Bency , Mave, Vidya , Hissar, Syed , Kapasa, Monica , Mboizi, Robert B. , Wobudeya, Eric , Crook, Angela M. , Palmer, Megan , Bhavani, Perumal K. , Welch, Steven B. , Thomason, Margaret J. , van der Zalm, Marieke M. , Aarnoutse, Rob , Musoke, Philippa , Love-Koh, James , Seddon, James A. , LeBeau, Kristen , Demers, Anne-Marie , Hesseling, Anneke C. , Kinikar, Aarti , Graham, Stephen M.

in Adolescent / Adults / Adverse events / Africa / Airway management / Antitubercular Agents - administration & dosage / Bacterial infections / Caregivers / Child / Child, Preschool / Childhood Diseases / Children / Diagnostics / Drug Administration Schedule / Drug dosages / Drug resistance / Drug Therapy, Combination / Female / Global Health / HIV / Human immunodeficiency virus / Humans / India / Infant / Infections / Infectious Disease / Intention to Treat Analysis / Isoniazid - administration & dosage / Laboratories / Male / Medical diagnosis / Medical research / Patient Acuity / Pediatrics / Population / Pyrazinamide - administration & dosage / Rifampin - administration & dosage / Software / Statistical analysis / Treatment Outcome / Tuberculosis / Tuberculosis - drug therapy

2022

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2022

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2022

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Journal Article

Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children

Mulenga, Veronica,

Wills, Genevieve H.,

McIlleron, Helen,

Choo, Louise,

Raichur, Priyanka,

Gibb, Diana M.,

Turkova, Anna,

Chabala, Chishala,

Joseph, Bency,

Mave, Vidya,

Hissar, Syed,

Kapasa, Monica,

Mboizi, Robert B.,

Wobudeya, Eric,

Crook, Angela M.,

Palmer, Megan,

Bhavani, Perumal K.,

Welch, Steven B.,

Thomason, Margaret J.,

van der Zalm, Marieke M.,

Aarnoutse, Rob,

Musoke, Philippa,

Love-Koh, James,

Seddon, James A.,

LeBeau, Kristen,

Demers, Anne-Marie,

Hesseling, Anneke C.,

Kinikar, Aarti,

Graham, Stephen M.

2022

Overview

Completing 6 months of treatment for tuberculosis in children is a challenge. In this open-label trial involving 1204 children in sub-Saharan Africa and India, 4 months of antituberculosis therapy was noninferior to 6 months of therapy.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adults

/ Adverse events

/ Africa

/ Airway management

/ Antitubercular Agents - administration & dosage

/ Bacterial infections