Journal Article

A Longitudinal Follow-Up Study of Affect in Children and Adults With Cornelia de Lange Syndrome

Oliver, Chris, Nelson, Lisa, Moss, Jo

2014

Overview

Studies of individuals with Cornelia de Lange syndrome (CdLS) have described changes in mood and behavior with age, although no empirical or longitudinal studies have been conducted. Caregivers of individuals with CdLS (N  =  67), cri du chat syndrome (CdCS; N  =  42), and Fragile X syndrome (FXS; N  =  142) completed the Mood, Interest and Pleasure Questionnaire (MIPQ) at Time 1 and 2 years later (Time 2). Scores on the MIPQ were significantly lower in the CdLS group compared with the CdCS and FXS groups at Time 1 and Time 2. Lower MIPQ scores were characteristic of older adolescents (> 15 years) and adults with CdLS. However, there were no significant differences in MIPQ scores between Time 1 and Time 2. Age and insistence on sameness predicted MIPQ scores in CdLS.

• Publisher: American Association on Intellectual and Developmental Disabilities,Taylor & Francis Ltd
• Subject: Adolescent / Adolescents / Adult / Adults / Affect - physiology / Age Differences / Age Factors / Anxiety / Autism / Biological and medical sciences / Caregivers / Child / Child, Preschool / Children / Cognition & reasoning / Comparative Analysis / Cri du chat syndrome / Cri-du-Chat Syndrome - physiopathology / De Lange syndrome / De Lange Syndrome - physiopathology / Emotional Response / Emotions / Female / Follow-Up Studies / Followup Studies / Fragile X Syndrome / Genetic Disorders / Humans / Interests / Longitudinal Studies / Male / Malformations of the nervous system / Medical sciences / Middle Aged / Mutation / Neurology / Older people / Oxidative stress / Phenotype / Pleasure / Predictive Value of Tests / Predictor Variables / Psychological Patterns / Questionnaires / Repair & maintenance / Scores / Self destructive behavior / Studies / Time / Young Adult