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Efficacy of Gemcitabine-based Chemotherapy in Clear Cell Sarcoma of Soft Tissue
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Efficacy of Gemcitabine-based Chemotherapy in Clear Cell Sarcoma of Soft Tissue
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Efficacy of Gemcitabine-based Chemotherapy in Clear Cell Sarcoma of Soft Tissue
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Journal Article
Efficacy of Gemcitabine-based Chemotherapy in Clear Cell Sarcoma of Soft Tissue
2020
Overview
Clear cell sarcoma (CCS) is an aggressive sarcoma subtype, resistant to conventional anthracycline-based chemotherapy and radiation. The diagnosis is often challenging due to similarities with malignant melanoma.
We aimed to analyse the activity of gemcitabine-based chemotherapy in a cohort of patients with CCS treated at the Royal Marsden Hospital.
Five patients with metastatic CCS received gemcitabine as first- or second-line systemic therapy. The median time-to-progression was 10 weeks. The median number of cycles of gemcitabine-based therapy was 3 (range=2-7 cycles). Median overall survival in our cohort was 66 months from the initial diagnosis but in the metastatic setting, the overall survival was reduced to 28 months.
Gemcitabine-based therapy has modest activity in CCS. There remains a significant unmet medical need for novel, effective therapies for this disease.
Publisher
International Institute of Anticancer Research
Subject
/ Adult
/ Antimetabolites, Antineoplastic - pharmacology
/ Antimetabolites, Antineoplastic - therapeutic use
/ Deoxycytidine - analogs & derivatives
/ Deoxycytidine - pharmacology
/ Deoxycytidine - therapeutic use
/ Female
/ Humans
/ Kinases
/ Lungs
/ Male
/ Melanoma
/ Patients
/ Proteins
/ Sarcoma
/ Sarcoma, Clear Cell - drug therapy
/ Soft Tissue Neoplasms - drug therapy
/ Surgery
/ Survival
/ Tumors
