Asset Details
Do you wish to reserve the book?
Fermented pickles improve gut microbiota and immune profile in women in a community trial in rural Pakistan
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Fermented pickles improve gut microbiota and immune profile in women in a community trial in rural Pakistan
Do you wish to request the book?
Fermented pickles improve gut microbiota and immune profile in women in a community trial in rural Pakistan
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Fermented pickles improve gut microbiota and immune profile in women in a community trial in rural Pakistan
2025
Overview
A gut microbiome-targeted diet can potentially mitigate chronic diseases, including malnutrition. In a prospective 12-week intervention trial, we evaluated the effects of six different plant-based fermented pickles (~ 50 g/day) on clinical, inflammatory, and gut microbiota parameters in a cohort of women (
n
= 230) in a rural setting with a high prevalence of undernutrition. Blood was collected at two, whereas stool was collected at three timepoints. Among fecal biomarkers, myeloperoxidase (MPO), Lipocalin-2 (LCN2), and 16S rRNA gene sequencing were measured at baseline, 8
th,
and 12
th
weeks. Overall, the compliance rate was > 70%. Among radish group, WBCs (
p
= 0.002, two-tailed paired T-test) decreased, whereas neutrophils and platelets decreased among both radish (
p
= 0.016,
p
= 0.017, two-tailed paired T-test) and carrot (
p
= 0.005,
p
= 0.006, two-tailed paired T-test) groups after intervention. Similarly, in lemon-chilli group, platelets decreased while mean corpuscular hemoglobin (MCH) increased (
p
< 0.001,
p
= 0.022, two-tailed paired T-test). In onion and lemon-chilli groups, α- (
р
=0.001 and
p
= 0.0005, Kruskal-Wallis Test, respectively) and β-diversity indices (
p
= 9e-04 and
p
= 0.022, pairwise PERMANOVA, respectively) were significantly increased, post-intervention. Linear discriminant analysis (LDA) of lemon-chilli group identified 25 bacterial taxa markers in 8
th
and 12
th
week, which included
Eggerthellaceae
and
Oscillospiraceae
,
Erysipelatoclostridiaceae
and
Subdoligranulum
. Correlation analysis revealed six taxa negatively associated with inflammatory markers such as C-reactive protein (CRP), LCN2, and platelets. Our study provides preliminary evidence that the consumption of traditional fermented pickles leads to beneficial changes in women’s hematological and gut microbiota profiles.
