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Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila
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Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila
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Journal Article
Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila
2016
Overview
Waddlia chondrophila
is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in cattle. Despite an increasing number of observational studies linking
W. chondrophila
infection to cattle abortion, little direct experimental evidence exists. Given this paucity of direct evidence the current study was carried out to investigate whether experimental challenge of pregnant cattle with
W. chondrophila
would result in infection and abortion. Nine pregnant Friesian-Holstein heifers received 2 × 10
8
inclusion forming units (IFU)
W. chondrophila
intravenously on day 105–110 of pregnancy, while four negative-control animals underwent mock challenge. Only one of the challenged animals showed pathogen-associated lesions, with the organism being detected in the diseased placenta. Importantly, the organism was re-isolated and its identity confirmed by whole genome sequencing, confirming Koch’s third and fourth postulates. However, while infection of the placenta was observed, the experimental challenge in this study did not confirm the abortifacient potential of the organism.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Abortion
/ Abortion, Septic - metabolism
/ Abortion, Septic - microbiology
/ Abortion, Septic - pathology
/ Abortion, Septic - veterinary
/ Animals
/ Cattle
/ Cattle Diseases - metabolism
/ Cattle Diseases - microbiology
/ Chlamydiales - pathogenicity
/ Female
/ Genomes
/ Gram-Negative Bacterial Infections - metabolism
/ Gram-Negative Bacterial Infections - pathology
/ Humanities and Social Sciences
/ Placenta
/ Placenta Diseases - metabolism
/ Placenta Diseases - microbiology
/ Placenta Diseases - pathology
/ Placenta Diseases - veterinary
/ Science
