Asset Details
Do you wish to reserve the book?
Integrative metabolomic and single-cell transcriptomic analysis of recurrent condyloma acuminatum in humans
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Integrative metabolomic and single-cell transcriptomic analysis of recurrent condyloma acuminatum in humans
Do you wish to request the book?
Integrative metabolomic and single-cell transcriptomic analysis of recurrent condyloma acuminatum in humans
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Integrative metabolomic and single-cell transcriptomic analysis of recurrent condyloma acuminatum in humans
2026
Overview
Condyloma acuminatum (CA), primarily caused by low-risk HPV6/11, is a benign proliferative disease that is difficult to cure and prone to recurrence. However, the molecular and immune mechanisms underlying relapse remain unclear. We combined metabolomic profiling with single-cell RNA sequencing to investigate recurrence-associated changes. Metabolomics revealed dysregulation of ascorbate and aldarate, glycerophospholipid, purine, and arginine/proline metabolism in recurrent CA. Single-cell analysis identified altered expression of metabolism-related genes (AMD1, GSTM3, ALDH3A1, GPX1, GPX4) in keratinocytes, associated with hyperproliferation, impaired differentiation, and ferroptosis resistance. Immune profiling identified transcriptionally distinct myeloid subpopulations in recurrent CA lesions, including M2 macrophages and dendritic cells. KEGG analysis indicated enrichment of antigen processing, phagosome, and endocytosis pathways in M2 macrophages, and antigen processing and viral carcinogenesis in dendritic cells, suggesting altered immune regulatory states. Notably, the key polyamine biosynthesis regulator AMD1 was downregulated in both M2 macrophages and dendritic cells in recurrent lesions, paralleling metabolic evidence of altered arginine-polyamine pathways. These findings suggest that recurrent CA involves coordinated metabolic dysregulation across keratinocytes and immune cells, highlighting potential targets for immunometabolic intervention.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/250
/ 631/67
/ 631/80
/ Adult
/ Blood
/ Condylomata Acuminata - genetics
/ Condylomata Acuminata - metabolism
/ Condylomata Acuminata - pathology
/ Condylomata Acuminata - virology
/ Dendritic Cells - metabolism
/ Female
/ Genes
/ Genomics
/ Humanities and Social Sciences
/ Humans
/ Male
/ Science
/ Single-Cell Analysis - methods
/ Software
