Asset Details
Do you wish to reserve the book?
Simple-synthesis VO₂ nanoparticles as robust nanozymes for synergistic antibacterial therapy and abscess repair
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Simple-synthesis VO₂ nanoparticles as robust nanozymes for synergistic antibacterial therapy and abscess repair
Do you wish to request the book?
Simple-synthesis VO₂ nanoparticles as robust nanozymes for synergistic antibacterial therapy and abscess repair
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Simple-synthesis VO₂ nanoparticles as robust nanozymes for synergistic antibacterial therapy and abscess repair
2025
Overview
Multidrug resistant (MDR) bacterial infections, particularly those involving methicillin-resistant Staphylococcus aureus (MRSA), pose a grave threat to global population health, necessitating novel therapeutic approaches capable of circumventing existing resistance mechanisms. Biomimetic enzymes, which generate bactericidal reactive oxygen species (ROS) by mimicking natural enzyme activity, represent a highly promising solution. This study reports a straightforward one-step synthesis method for vanadium dioxide (VO₂) nanoparticles, which function as potent biomimetic enzymes exhibiting both oxidase-like and peroxidase-like activities. When combined with near-infrared laser irradiation (808 nm, 1 W/cm²) for photothermal therapy (PTT), these VO₂ nanoparticles not only mediate local hyperthermia with a photothermal conversion rate of up to 36.9%, but also significantly enhance ROS generation through biomimetic catalysis. This achieves potent synergistic effects between photothermal therapy and chemodynamic therapy (CDT). This combined therapy exhibits potent antibacterial activity against suspended methicillin-resistant Staphylococcus aureus (MRSA) and effectively disrupts preformed biofilms. Furthermore, in a subcutaneous abscess mouse model, VO₂-mediated PTT-CDT treatment efficiently eradicated bacteria, alleviated local inflammation, promoted tissue repair and angiogenesis. In summary, this readily synthesised VO₂ nanozyme system offers an efficient and translatable therapeutic strategy for tackling challenging multidrug-resistant bacterial infections.
Graphical Abstract
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ Animals
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Antiinfectives and antibacterials
/ Bacteria
/ Biofilms
/ Chemistry and Materials Science
/ Enzymes
/ Humans
/ Lasers
/ Methicillin-Resistant Staphylococcus aureus - drug effects
/ Mice
/ Multidrug-resistant (MDR) bacterial infections
/ Potash
/ Reactive Oxygen Species - metabolism
/ Staphylococcal Infections - drug therapy
/ Staphylococcal Infections - therapy
/ Therapy
/ Vanadium
/ Vanadium Compounds - chemistry
/ Vanadium Compounds - pharmacology
