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Morus alba leaf extract mediates neuroprotection against glyphosate-induced toxicity and biochemical alterations in the brain
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Morus alba leaf extract mediates neuroprotection against glyphosate-induced toxicity and biochemical alterations in the brain
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Journal Article
Morus alba leaf extract mediates neuroprotection against glyphosate-induced toxicity and biochemical alterations in the brain
2017
Overview
Recent studies demonstrate that glyphosate exposure is associated with oxidative stress and some neurological disorders such as Parkinson’s pathology. Therefore, phytochemicals, in particular phenolic compounds, have attracted increasing attention as potential agents for neuroprotection. In the present study, we investigate the impact of glyphosate on the rat brain following i.p. injection and the possible molecular target of neuroprotective activity of the phenolic fraction from
Morus alba
leaf extract (MALE) and its ability to reduce oxidative damage in the brain. Wistar rats from 180 to 240 g were i.p. treated with a single dose of glyphosate (100 mg kg
−1
b.w.) or MALE (100 μg mL
−1
kg
−1
b.w.) for 2 weeks. Brain homogenates were used to evaluate neurotoxicity induced by the pesticide. For this, biochemical parameters were measured. Data shows that MALE regulated oxidative stress and counteracted glyphosate-induced deleterious effects and oxidative damage in the brain, as it abrogated LDH, protein carbonyls, and malonyldialdehyde. MALE also appears to be able to scavenge H
2
O
2
levels, maintain iron and Ca
2+
homeostasis, and increase SOD activity. Thus, in vivo results showed that mulberry leaf extract is a potent protector against glyphosate-induced toxicity, and its protective effect could result from synergism or antagonism between the various bioactive phenolic compounds in the acetonic fraction from
M. alba
leaf extract.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
