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Evaluation of the In Vitro Biocompatibility of PEDOT:Nafion Coatings

by Pavan, Barbara , Guzzo, Sonia , Murgia, Mauro , Carli, Stefano , Lunghi, Alice , Bianchi, Michele

in Atomic force microscopy / Biocompatibility / cell adhesion / Cell culture / Cell proliferation / Cell viability / Coatings / conducting polymers / Contact angle / Cytology / Cytotoxicity / Dispersion / Ethanol / Evaluation / Fibroblasts / Fluorescence / Fluorescence microscopy / Glass substrates / In vivo methods and tests / Investigations / L-Lactate dehydrogenase / Lactate dehydrogenase / Lactic acid / Life sciences / Morphology / organic bioelectronics / Organic light emitting diodes / Polymers / Polystyrene / Polystyrene resins / Scanning electron microscopy / Software / surface coating / Topography / Toxicity / Transistors

2021

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Evaluation of the In Vitro Biocompatibility of PEDOT:Nafion Coatings

by Pavan, Barbara , Guzzo, Sonia , Murgia, Mauro , Carli, Stefano , Lunghi, Alice , Bianchi, Michele

2021

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Evaluation of the In Vitro Biocompatibility of PEDOT:Nafion Coatings

by Pavan, Barbara , Guzzo, Sonia , Murgia, Mauro , Carli, Stefano , Lunghi, Alice , Bianchi, Michele

2021

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Journal Article

Evaluation of the In Vitro Biocompatibility of PEDOT:Nafion Coatings

Pavan, Barbara,

Guzzo, Sonia,

Murgia, Mauro,

Carli, Stefano,

Lunghi, Alice,

Bianchi, Michele

2021

Overview

Poly(3,4-ethylenedioxythiophene)-Nafion (PEDOT:Nafion) is emerging as a promising alternative to PEDOT-polystyrene sulfonate (PEDOT:PSS) in organic bioelectronics. However, the biocompatibility of PEDOT:Nafion has not been investigated to date, limiting its deployment toward in vivo applications such as neural recording and stimulation. In the present study, the in vitro cytotoxicity of PEDOT:Nafion coatings, obtained by a water-based PEDOT:Nafion formulation, was evaluated using a primary cell culture of rat fibroblasts. The surface of PEDOT:Nafion coating was characterized by Atomic Force Microscopy (AFM) and water contact angle measurements. Fibroblasts adhesion and morphology was investigated by scanning electron microscopy (SEM) and AFM measurements. Cell proliferation was assessed by fluorescence microscopy, while cell viability was quantified by 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT), lactate dehydrogenase (LDH) and neutral red assays. The results showed that PEDOT:Nafion coatings obtained by the water dispersion were not cytotoxic, making the latter a reliable alternative to PEDOT:PSS dispersion, especially in terms of chronic in vivo applications.

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Publisher

MDPI AG,MDPI

Subject

Atomic force microscopy