Asset Details
Do you wish to reserve the book?
CD8+ T cells induce cachexia during chronic viral infection
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
CD8+ T cells induce cachexia during chronic viral infection
Do you wish to request the book?
CD8+ T cells induce cachexia during chronic viral infection
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
CD8+ T cells induce cachexia during chronic viral infection
2019
Overview
Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections. Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC). In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8
+
T cells in IAC. Cytokines linked to cancer-associated cachexia did not contribute to IAC. Instead, virus-specific CD8
+
T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores. These changes occurred at a time point that preceded the peak of the CD8
+
T cell response and required T cell–intrinsic type I interferon signaling and antigen-specific priming. Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8
+
T cells in IAC.
Cachexia manifests in cancer, chronic inflammation and infections. Bergthaler and colleagues show that CD8
+
T cells mediate infection-associated cachexia in a manner dependent on T cell–intrinsic type I IFN signaling and antigen recognition.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Adipose Tissue - diagnostic imaging
/ Animals
/ Antigens
/ Biomedical and Life Sciences
/ Cachexia
/ Cachexia - diagnostic imaging
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - metabolism
/ Female
/ Interferon Type I - metabolism
/ Lymphocyte Activation - immunology
/ Lymphocytic choriomeningitis virus
/ Magnetic Resonance Imaging - methods
/ Male
/ Mice
