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First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer

by Pernas, Sonia , Nowecki, Zbigniew , Bidard, François-Clément , Mayer, Erica L. , He, Wei , Moreau, Lionel , Bianchini, Giampaolo , Turner, Nicholas C. , Huang-Bartlett, Cynthia , Jung, Kyung Hae , Park, Yeon Hee , Chen, Shin-Cheh , McClain, Sasha , Janni, Wolfgang , Chia, Stephen , Klinowska, Teresa , Fasching, Peter A. , Iwata, Hiroji , Brufsky, Adam , Kalinsky, Kevin , Ma, Cynthia , Gal-Yam, Einav Nili , Pascual, Javier , Karadurmus, Nuri , Cristofanilli, Massimo

in Adult / Aged / Aged, 80 and over / Aminopyridines / Antineoplastic Agents, Hormonal - administration & dosage / Antineoplastic Agents, Hormonal - adverse effects / Antineoplastic Combined Chemotherapy Protocols - administration & dosage / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Antitumor activity / Aromatase / Aromatase Inhibitors - administration & dosage / Aromatase Inhibitors - adverse effects / Azetidines / Benzimidazoles / Breast Cancer / Breast Neoplasms - blood / Breast Neoplasms - drug therapy / Breast Neoplasms - genetics / Breast Neoplasms - mortality / Breast Neoplasms, Male - blood / Breast Neoplasms, Male - drug therapy / Breast Neoplasms, Male - genetics / Breast Neoplasms, Male - mortality / Cancer / Circulating Tumor DNA - blood / Circulating Tumor DNA - genetics / Cyclin-dependent kinase 4 / Cyclin-Dependent Kinase 4 - antagonists & inhibitors / Cyclin-Dependent Kinase 6 - antagonists & inhibitors / Cyclin-dependent kinases / Ecology, environment / ErbB-2 protein / Estrogen Receptor alpha - antagonists & inhibitors / Estrogen Receptor alpha - genetics / Estrogen Receptor alpha - metabolism / Estrogen receptors / Estrogens / Female / Follow-Up Studies / Genetics / Genetics General / Health / Hematology / Humans / International organizations / Isoquinolines / Kinases / Life Sciences / Metastasis / Middle Aged / Mutation / Oncology / Patients / Piperazines / Placebos / Progression-Free Survival / Protein Kinase Inhibitors - administration & dosage / Protein Kinase Inhibitors - adverse effects / Public health / Purines / Pyridines / Quality of life / Questionnaires / Surveillance / Survival / Treatment Outcome / Treatments in Oncology / Tumors

2025

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First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer

2025

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First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer

2025

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Journal Article

First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer

Pernas, Sonia,

Nowecki, Zbigniew,

Bidard, François-Clément,

Mayer, Erica L.,

He, Wei,

Moreau, Lionel,

Bianchini, Giampaolo,

Turner, Nicholas C.,

Huang-Bartlett, Cynthia,

Jung, Kyung Hae,

Park, Yeon Hee,

Chen, Shin-Cheh,

McClain, Sasha,

Janni, Wolfgang,

Chia, Stephen,

Klinowska, Teresa,

Fasching, Peter A.,

Iwata, Hiroji,

Brufsky, Adam,

Kalinsky, Kevin,

Ma, Cynthia,

Gal-Yam, Einav Nili,

Pascual, Javier,

Karadurmus, Nuri,

Cristofanilli, Massimo

2025

Overview

In patients with advanced breast cancer, switching to camizestrant with a CDK4/6 inhibitor after ESR1 -mutation detection (and before disease progression) led to significantly longer progression-free survival.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Aged

/ Aged, 80 and over

/ Aminopyridines

/ Antineoplastic Agents, Hormonal - administration & dosage

/ Antineoplastic Agents, Hormonal - adverse effects

/ Antineoplastic Combined Chemotherapy Protocols - administration & dosage