Journal Article

The Effect of Whole Body Vibration Training on Bone and Muscle Function in Children With Osteogenesis Imperfecta

Crabtree, Nicola, Shaw, Nick, Scott, Janis, Högler, Wolfgang, Padidela, Raja, Arundel, Paul, Bishop, Nick, Mughal, M Zulf, Nightingale, Peter

2017

Overview

ContextOsteogenesis imperfecta (OI) is associated with reduced muscle size, dynamic muscle function, and mobility.ObjectiveTo assess the effect of whole body vibration (WBV) on bone density and geometry, muscle size and function, mobility, and balance in children with OI.DesignRandomized controlled pilot trial.SettingTertiary pediatric research center.ParticipantsTwenty-four children (5 to 16 years) with OI types 1, 4, and limited mobility [Child Health Assessment Questionnaire (CHAQ) score ≥ 0.13] recruited in sex- and pubertal stage-matched pairs. Incident fractures in two boys (WBV arm) led to exclusion of two prepubertal pairs.InterventionFive months of WBV training (3 × 3 minutes twice daily) or regular care.Main Outcome MeasuresBone and muscle variables measured by dual-energy X-ray absorptiometry (spine, hip, total body) and peripheral quantitative computed tomography (tibia). Mobility assessed by 6-minute walk tests and CHAQ; dynamic muscle function by mechanography.ResultsAll participants had reduced walking distances and muscle function (P < 0.001). Body mass index z score was associated with higher CHAQ scores (ρ + 0.552; P = 0.005) and lower walking and two-leg jumping performance (ρ − 0.405 to −0.654, P < 0.05). The WBV and control groups did not differ in the 5-month changes in bone. Total lean mass increased more in the WBV group [+1119 g (+224 to +1744)] compared with controls [+635 g (−951 to +1006)], P = 0.01, without improving mobility, muscle function, or balance.ConclusionsThe increase in lean mass without changes in muscle function or bone mass suggests reduced biomechanical responsiveness of the muscle-bone unit in children with OI.This randomized controlled study of WBV in OI children demonstrates improvements in lean mass but not in muscle function or bone mass, indicating reduced responsiveness of OI bones to WBV.

• Publisher: Endocrine Society,Copyright Oxford University Press,Oxford University Press
• Subject: Absorptiometry, Photon / Adolescent / Arm / Balance / Body mass index / Body size / Bone Density / Bone mass / Child / Child, Preschool / Children / Computed tomography / Dual energy X-ray absorptiometry / Female / Fractures / Hip / Hip - diagnostic imaging / Humans / Jumping / Male / Mobility / Mobility Limitation / Muscle function / Muscle, Skeletal - pathology / Muscle, Skeletal - physiopathology / Organ Size / Osteogenesis / Osteogenesis imperfecta / Osteogenesis Imperfecta - physiopathology / Osteogenesis Imperfecta - rehabilitation / Pediatrics / Postural Balance - physiology / Spine / Spine - diagnostic imaging / Tibia / Tibia - diagnostic imaging / Tomography, X-Ray Computed / Treatment Outcome / Vibration - therapeutic use / Walk Test / Walking