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Arginine Residues in the C-terminal and their Relationship with the Analgesic Activity of the Toxin from the Chinese Scorpion Buthus martensii Karsch (BmK AGP-SYPU1)
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Arginine Residues in the C-terminal and their Relationship with the Analgesic Activity of the Toxin from the Chinese Scorpion Buthus martensii Karsch (BmK AGP-SYPU1)
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Arginine Residues in the C-terminal and their Relationship with the Analgesic Activity of the Toxin from the Chinese Scorpion Buthus martensii Karsch (BmK AGP-SYPU1)
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Journal Article
Arginine Residues in the C-terminal and their Relationship with the Analgesic Activity of the Toxin from the Chinese Scorpion Buthus martensii Karsch (BmK AGP-SYPU1)
2012
Overview
In this study, we investigated the functional role of arginines in the C-terminal (65–67) of BmK AGP-SYPU1, an analgesic peptide from the Chinese scorpion
Buthus martensii
Karsch. Using site-directed mutagenesis, arginines at the C-terminal (65–66) were deleted or added to the C-terminal (67). The genes for three mutants of BmK AGP-SYPU1 were obtained by PCR. An analgesic activity assay was used to evaluate the role of arginine residues in the analgesic activity. The three-dimensional structure of BmK AGP-SYPU1 was established by homology modeling. As a result, we showed that the arginines in the C-terminal are crucial for the analgesic activity and may be located at analgesic functional sites. Our work has implications for further modification of scorpion toxins to obtain new analgesic peptides with enhanced activity.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Analgesics - isolation & purification
/ Animals
/ Arginine
/ Arthropod Proteins - chemistry
/ Arthropod Proteins - genetics
/ Arthropod Proteins - isolation & purification
/ Arthropod Proteins - pharmacology
/ Biological and medical sciences
/ Chemistry and Materials Science
/ Fundamental and applied biological sciences. Psychology
/ genes
/ Genetics
/ Mice
/ mutants
/ Mutation
/ Peptides
/ Structure-Activity Relationship
/ Toxins
/ Toxins, Biological - chemistry
/ Toxins, Biological - genetics
