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Comparison of electroencephalogram between propofol- and thiopental-induced anesthesia for awareness risk in pregnant women
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Comparison of electroencephalogram between propofol- and thiopental-induced anesthesia for awareness risk in pregnant women
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Journal Article
Comparison of electroencephalogram between propofol- and thiopental-induced anesthesia for awareness risk in pregnant women
2020
Overview
There have been few comparative studies using electroencephalogram (EEG) spectral characteristics during the induction of general anesthesia for cesarean section. This retrospective study investigated the differences in the depth of anesthesia through EEG analysis between propofol- and thiopental-induced anesthesia. We reviewed data of 42 patients undergoing cesarean section who received either thiopental (5 mg/kg) or propofol (2 mg/kg). EEG data were extracted from the bispectral index (BIS) monitor, and 10-second segments were selected from the following sections: 1) Stage I, BIS below 60 after induction; 2) Stage II, after intubation completion; 3) Stage III, end-tidal sevoflurane above 0 vol%. The risk of awareness was represented by the BIS and entropy measures. In Stage III, the thiopental group (n = 20) showed significantly higher BIS value than the propofol group (n = 22) (67.9 [18.66] vs 44.5 [20.63], respectively,
p
= 0.002). The thiopental group had decreased slow-delta oscillations and increased beta-oscillations as compared to the propofol group in Stages II and III (
p
< 0.05). BIS, spectral entropy, and Renyi permutation entropy were also higher in the thiopental group at Stages II and III (
p
< 0.05). In conclusion, frontal spectral EEG analysis demonstrated that propofol induction maintained a deeper anesthesia than thiopental in pregnant women.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 692/308
/ Adult
/ Anesthesia, Obstetrical - adverse effects
/ Anesthesia, Obstetrical - methods
/ Cesarean Section - adverse effects
/ EEG
/ Entropy
/ Female
/ Humanities and Social Sciences
/ Humans
/ Intraoperative Awareness - diagnosis
/ Intraoperative Awareness - epidemiology
/ Intraoperative Awareness - etiology
/ Intraoperative Neurophysiological Monitoring - methods
/ Intraoperative Neurophysiological Monitoring - statistics & numerical data
/ Propofol
/ Propofol - administration & dosage
/ Risk Assessment - statistics & numerical data
/ Science
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