Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

by Masoodi, Mojgan , Pajvani, Utpal B. , Brosch, Mario , Geng, Yana , Sun, Zhaoli , Guillot, Adrien , Monga, Satdarshan P. , Argemi, Josepmaria , Melms, Johannes , Qie, Jingran , Yin, Chuan , Kanzaki, Hiroaki , Lee, Youngmin A. , Yin, Deqi , Hampe, Jochen , Tacke, Frank , Oertel, Michael , Stockwell, Brent R. , Savage, Thomas , Fujiwara, Naoto , Fallowfield, Jonathan A. , Augustin, Hellmut G. , Filliol, Aveline , Lan, Tian , Schwabe, Robert F. , Lehrich, Brandon M. , Goyal, Dhruv M. , Remotti, Helen , Haeusler, Rebecca A. , Rajbhandari, Presha , Arpaia, Nicholas , Ray, Kevin C. , Ravi, Samhita , Liu, Silvia , Hoshida, Yujin , Sugimoto, Atsushi , Hernandez, Celine , Steinman, Jonathan B. , Blockley-Powell, Storm K. , Yasaka, Tyler M. , Bataller, Ramon , Peiseler, Moritz , Kendall, Timothy J. , Sun, Qiuyan , Izar, Benjamin , Wang, Guanxiong , Saito, Yoshinobu , Lee, Ki Hong , Steffani, Marcella , Neelakantan, Taruna V.

in 13 / 13/95 / 38/39 / 38/91 / 631/80/304 / 631/80/86 / 64 / 64/60 / 96 / Alcohol / Animals / Cell death / Cell size / Cytochrome / Cytochrome P450 / Cytochromes P450 / Depletion / Detoxification / Fatty Liver - metabolism / Fatty Liver - pathology / Female / Fibrosis / Gene deletion / Gene expression / Hepatic Stellate Cells - cytology / Hepatic Stellate Cells - metabolism / Hepatic Stellate Cells - pathology / Hepatocytes / Hepatocytes - cytology / Hepatocytes - metabolism / Hepatocytes - pathology / Humanities and Social Sciences / Humans / Liver / Liver - cytology / Liver - metabolism / Liver - pathology / Liver diseases / Liver Regeneration / Male / Metabolism / Metabolites / Mice / multidisciplinary / Organ Size / R-Spondins - genetics / R-Spondins - metabolism / Regeneration / Science / Science (multidisciplinary) / Stellate cells / Thrombospondins - deficiency / Thrombospondins - genetics / Thrombospondins - metabolism / Toxins / Wnt protein / Wnt Signaling Pathway / Zonation

2025

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

2025

Confirm

Do you wish to request the book?

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

2025

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Masoodi, Mojgan,

Pajvani, Utpal B.,

Brosch, Mario,

Geng, Yana,

Sun, Zhaoli,

Guillot, Adrien,

Monga, Satdarshan P.,

Argemi, Josepmaria,

Melms, Johannes,

Qie, Jingran,

Yin, Chuan,

Kanzaki, Hiroaki,

Lee, Youngmin A.,

Yin, Deqi,

Hampe, Jochen,

Tacke, Frank,

Oertel, Michael,

Stockwell, Brent R.,

Savage, Thomas,

Fujiwara, Naoto,

Fallowfield, Jonathan A.,

Augustin, Hellmut G.,

Filliol, Aveline,

Lan, Tian,

Schwabe, Robert F.,

Lehrich, Brandon M.,

Goyal, Dhruv M.,

Remotti, Helen,

Haeusler, Rebecca A.,

Rajbhandari, Presha,

Arpaia, Nicholas,

Ray, Kevin C.,

Ravi, Samhita,

Liu, Silvia,

Hoshida, Yujin,

Sugimoto, Atsushi,

Hernandez, Celine,

Steinman, Jonathan B.,

Blockley-Powell, Storm K.,

Yasaka, Tyler M.,

Bataller, Ramon,

Peiseler, Moritz,

Kendall, Timothy J.,

Sun, Qiuyan,

Izar, Benjamin,

Wang, Guanxiong,

Saito, Yoshinobu,

Lee, Ki Hong,

Steffani, Marcella,

Neelakantan, Taruna V.

2025

Overview

Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood 1 , 2 , 3 , 4 – 5 . Here we demonstrate that genetic depletion of HSCs changes WNT activity and zonation of hepatocytes, leading to marked alterations in liver regeneration, cytochrome P450 metabolism and injury. We identify R-spondin 3 (RSPO3), an HSC-enriched modulator of WNT signalling, as responsible for these hepatocyte-regulatory effects of HSCs. HSC-selective deletion of Rspo3 phenocopies the effects of HSC depletion on hepatocyte gene expression, zonation, liver size, regeneration and cytochrome P450-mediated detoxification, and exacerbates alcohol-associated and metabolic dysfunction-associated steatotic liver disease. RSPO3 expression decreases with HSC activation and is inversely associated with outcomes in patients with alcohol-associated and metabolic dysfunction-associated steatotic liver disease. These protective and hepatocyte-regulating functions of HSCs via RSPO3 resemble the R-spondin-expressing stromal niche in other organs and should be integrated into current therapeutic concepts. Hepatic stellate cells regulate hepatocyte functions via R-spondin 3.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 13/95

/ 38/39

/ 38/91

/ 631/80/304

/ 631/80/86

/ 64

/ 64/60