Journal Article

Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline

Le Grand, Quentin, Mishra, Aniket, Berr, Claudine, Helmer, Catherine, Neuffer, Jeanne, Leffondre, Karen, Trégouët, David‐Alexandre, Moreno, Elisa, Tzourio, Christophe, Wagner, Maude, Proust‐Lima, Cécile, Foubert‐Samier, Alexandra, Debette, Stéphanie, Samieri, Cécilia

2024

Overview

INTRODUCTION Evaluating whether genetic susceptibility modifies the impact of lifestyle‐related factors on dementia is critical for prevention. METHODS We studied 5170 participants from a French cohort of older persons free of dementia at baseline and followed for up to 17 years. The LIfestyle for BRAin health risk score (LIBRA) including 12 modifiable factors was constructed at baseline (higher score indicating greater risk) and was related to both subsequent cognitive decline and dementia incidence, according to genetic susceptibility to dementia (reflected by the apolipoprotein E [APOE] ε4 allele and a genetic risk score [GRS]). RESULTS The LIBRA was associated with higher dementia incidence, with no significant effect modification by genetics (hazard ratio for one point score = 1.09 [95% confidence interval, 1.05; 1.13]) in APOE ε4 non‐carriers and = 1.15 [1.08; 1.22] in carriers; P = 0.15 for interaction). Similar findings were obtained with the GRS and with cognitive decline. DISCUSSION Lifestyle‐based prevention may be effective whatever the genetic susceptibility to dementia.

• Publisher: John Wiley & Sons, Inc,Alzheimer's Association / Wiley,John Wiley and Sons Inc
• Subject: Aged / Aging / Alcohol / Alzheimer's disease / apolipoprotein E / Apolipoprotein E4 - genetics / Apolipoproteins / Blood pressure / Body mass index / Brain / Brain health / Brain research / Cardiovascular disease / Cholesterol / Cognition / Cognition & reasoning / cognitive decline / Cognitive Dysfunction - genetics / Cognitive impairment / Cohort Studies / Dementia / Dementia - epidemiology / Dementia - genetics / Diabetes / Disease prevention / Environmental risk / Fasting / Female / France / Genetic Predisposition to Disease / genetic risk score / Genetic susceptibility / Genetics / Genomes / Health care / Health risk assessment / Health risks / Human genetics / Human health and pathology / Humans / Hyperlipidemia / Hypertension / Incidence / Life Sciences / Life Style / Lifestyles / Male / modifiable risk factors / Neurons and Cognition / Neuropsychology / Obesity / Older people / Populations and Evolution / Prevention / Psychiatrics and mental health / Risk Factors / Santé publique et épidémiologie / Sociodemographics / Susceptibility