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Programmed Death-Ligand 1 and Programmed Death-Ligand 2 Expression Can Affect Prognosis in Extramammary Paget’s Disease
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Programmed Death-Ligand 1 and Programmed Death-Ligand 2 Expression Can Affect Prognosis in Extramammary Paget’s Disease
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Journal Article
Programmed Death-Ligand 1 and Programmed Death-Ligand 2 Expression Can Affect Prognosis in Extramammary Paget’s Disease
2021
Overview
Extramammary Paget's disease (EMPD) is a type of carcinoma that usually progresses slowly but may cause metastasis and subsequent death of patients. We investigated the relationship between the expression of programmed death-ligand 1 (PD-L1)/programmed death-ligand 2 (PD-L2) and stromal CD8
tumor-infiltrating lymphocytes (TILs) in EMPD and clinicopathological findings, including prognosis.
We examined 47 cases of EMPD and performed immunohistochemical staining of formalin-fixed paraffin-embedded full-face sections.
PD-L1 expression in tumor cells was observed in 13 cases (27.7%) while PD-L2 expression was observed in 21 cases (44.7%). The cumulative postoperative recurrence-free rate in the group with positivity for PD-L1 and/or PD-L2 with a low CD8
TIL count was significantly lower than that of the corresponding group with a high CD8
TIL count and of the PD-L1- and PD-L2-negative group (p=0.026).
The expression of PD-L1/PD-L2 in tumor cells was shown to be a factor for poor prognosis.
Publisher
International Institute of Anticancer Research
Subject
/ Antigens
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - metabolism
/ CD8-Positive T-Lymphocytes - pathology
/ Death
/ Disease
/ Female
/ Humans
/ Ligands
/ Lymphocytes, Tumor-Infiltrating - immunology
/ Lymphocytes, Tumor-Infiltrating - metabolism
/ Lymphocytes, Tumor-Infiltrating - pathology
/ Male
/ Melanoma
/ Paget Disease, Extramammary - genetics
/ Paget Disease, Extramammary - immunology
/ Paget Disease, Extramammary - mortality
/ Paget Disease, Extramammary - pathology
/ Penis
/ Programmed Cell Death 1 Ligand 2 Protein - genetics
/ Programmed Cell Death 1 Ligand 2 Protein - metabolism
/ Tumor-infiltrating lymphocytes
/ Tumors
