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Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation
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Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation
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Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation
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Journal Article
Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation
2025
Overview
Quiescent muscle stem cells (MuSCs) respond to exercise; however, the coordinated regulation of increased loading, exerkines, and quiescence signaling remains unclear. We found that increased loading reduces calcitonin receptor (CalcR) expression, and forced activation of protein kinase A (PKA), a downstream of CalcR signaling, suppresses MuSC proliferation. Although MuSC-specific
Calcr
knockout (C-cKO) alone is insufficient, exercised C-cKO mice exhibit significant MuSC proliferation independent of increased loading. Reinforcement of CalcR signaling, either through PKA induction or Yap1 depletion, suppresses MuSC proliferation. Load-independent MuSC proliferation is also suppressed by the deletion of
gp130
in C-cKO mice. Serum from exercised mice recapitulates MuSC proliferation in all analyzed muscles of sedentary C-cKO mice, which is abrogated by anti-IL-6 antibodies, and we find cross-talk between CalcR and gp130 signaling via Yap1 phosphorylation. Together, our findings reveal an integrated mechanism by which increased loading, exerkine-gp130, and CalcR signaling converge to fine-tune MuSC activity during exercise.
Here they show that muscle stem cells lacking calcitonin receptor (CalcR) undergo proliferation in running-exercised mice, independent of mechanical load, and demonstrate that CalcR functions to suppress activation of exerkine (IL-6)-gp130–YAP axis.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/31
/ 13/51
/ 13/95
/ 64/60
/ Adaptor Proteins, Signal Transducing - genetics
/ Adaptor Proteins, Signal Transducing - metabolism
/ Animals
/ Cyclic AMP-Dependent Protein Kinases - metabolism
/ Cytokine Receptor gp130 - genetics
/ Cytokine Receptor gp130 - metabolism
/ Exercise
/ Humanities and Social Sciences
/ Kinases
/ Load
/ Male
/ Mice
/ Muscle, Skeletal - metabolism
/ Muscles
/ Physical Conditioning, Animal - physiology
/ Receptors, Calcitonin - genetics
/ Receptors, Calcitonin - metabolism
/ Science
