Journal Article

Promoting medication adherence among patients with bipolar disorder: a multicenter randomized controlled trial of a multifaceted intervention

Pakpour, A. H., Lin, C.-Y., Saffari, M., Ahmadzad Asl, M., Webb, T. L., Modabbernia, A.

2017

Overview

The present research aimed to investigate the efficacy of a multifaceted intervention that included motivational interviewing (MI) and psychoeducation in improving medication adherence (MA) among patients with bipolar disorder (BD). A multicenter, cluster randomized, observer-blind, controlled, parallel-group trial was conducted in ten academic centers in Iran. Patients with BD were randomly assigned to the experimental group (EXP; n = 136) or the usual care group (UC; n = 134). The EXP group received five sessions of MI and psychoeducation together with their family members. The primary outcome measure was changes in scores on the Medication Adherence Rating Scale from baseline to 6 months post-intervention. Other outcome measures included serum levels of mood stabilizers, clinical symptoms, quality of life, as well as measures of intention, beliefs about medicine, perceived behavioral control, automaticity, action and coping planning, and adverse reactions. Medication adherence improved over time in both groups, but patients in the EXP group improved more (baseline score: 6.03; score at the sixth month: 9.55) than patients in the UC group (baseline score: 6.17; score at the sixth month: 6.67). In addition, patients in the EXP group showed greater improvement than patients in the UC group in almost all secondary outcomes 6 months following the intervention. Multifaceted interventions that include motivational-interviewing and psychoeducation can significantly improve MA and clinical and functional outcomes in patients with BD. The trial was registered with theClinicalTrials.gov database (NCT02241863) https://clinicaltrials.gov/ct2/show/NCT02241863.

• Publisher: Cambridge University Press
• Subject: Action control / Adherence / Adult / Aftercare / Automaticity / Automation / Behavior modification / Bipolar disorder / Bipolar Disorder - drug therapy / Bipolar Disorder - physiopathology / Child development / Clinical trials / Coping / Critical incidents / Drug therapy / Drugs / Efficacy / Emotions / Female / Functional impairment / Groups / Health Promotion - methods / HIV / Human immunodeficiency virus / Humans / Intervention / Interviews / Locus of control / Male / Measures / Medical research / Medication adherence / Medication Adherence - psychology / Medication Adherence - statistics & numerical data / Medicine / Middle Aged / Mood / mood stabilizer / Motivation / Motivational interviewing / Motivational Interviewing - methods / Original Articles / Outcome Assessment (Health Care) / Patient compliance / Patient Education as Topic / Patients / Perceived control / Psychiatry / psychoeducation / Psychoeducational treatment / Psychotherapy - methods / Quality of life / Registration / Relatives / Research centers / Schizophrenia / Serum / Serum levels / Single-Blind Method / Tranquilizing Agents - blood