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Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma

by Sun, Ying , Yang, Kun-Yu , Mao, Yan-Ping , Du, Xiao-Jing , Liu, Xu , Zhou, Guan-Qun , Li, Wen-Fei , Guo, Ying , Zheng, Bao-Min , Li, Ying-Qin , Sun, Yan , Long, Guo-Xian , Wang, Xi-Cheng , Shi, Mei , Tian, Ye , Li, Yu-Hong , Xiao, Yun , Hu, Guo-Qing , Zang, Jian , Zhang, Ning , Han, Fei , Hu, Wei-Han , Long, Jin-Hua , Guo, Rui , Su, Qiong-Fei , Li, Ling , Wang, Si-Yang , Chen, Lei , Chen, Yu-Pei , Li, Jin-Gao , Sun, Rui , Liu, Qiao-Dan , Jin, Feng , Zou, Li , Liang, Shao-Qiang , Mo, Hao-Yuan , Xie, Fang-Yun , Zhu, Xiao-Dong , Cheng, Zhi-Bin , Liu, Na , Xu, Cheng , Huang, Jing , Zhang, Yuan , Chua, Melvin L. K , Ma, Jun , Lv, Jia-Wei , Tang, Ling-Long

in Adolescent / Adult / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Cancer therapies / Chemoradiotherapy / Chemotherapy / Cisplatin / Cisplatin - administration & dosage / Cisplatin - adverse effects / Clinical trials / Death / Deoxycytidine - administration & dosage / Deoxycytidine - adverse effects / Deoxycytidine - analogs & derivatives / Female / Gemcitabine / Humans / Induction Chemotherapy - adverse effects / Leukopenia - chemically induced / Male / Medical prognosis / Metastases / Metastasis / Middle Aged / Nasopharyngeal carcinoma / Nasopharyngeal Carcinoma - drug therapy / Nasopharyngeal Carcinoma - therapy / Nausea / Neutropenia / NMR / Nuclear magnetic resonance / Oncology / Patients / Platinum / Radiation therapy / Survival / Survival Analysis / Throat cancer / Thrombocytopenia / Vomiting / Young Adult

2019

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2019

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2019

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Journal Article

Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma

Sun, Ying,

Yang, Kun-Yu,

Mao, Yan-Ping,

Du, Xiao-Jing,

Liu, Xu,

Zhou, Guan-Qun,

Li, Wen-Fei,

Guo, Ying,

Zheng, Bao-Min,

Li, Ying-Qin,

Sun, Yan,

Long, Guo-Xian,

Wang, Xi-Cheng,

Shi, Mei,

Tian, Ye,

Li, Yu-Hong,

Xiao, Yun,

Hu, Guo-Qing,

Zang, Jian,

Zhang, Ning,

Han, Fei,

Hu, Wei-Han,

Long, Jin-Hua,

Guo, Rui,

Su, Qiong-Fei,

Li, Ling,

Wang, Si-Yang,

Chen, Lei,

Chen, Yu-Pei,

Li, Jin-Gao,

Sun, Rui,

Liu, Qiao-Dan,

Jin, Feng,

Zou, Li,

Liang, Shao-Qiang,

Mo, Hao-Yuan,

Xie, Fang-Yun,

Zhu, Xiao-Dong,

Cheng, Zhi-Bin,

Liu, Na,

Xu, Cheng,

Huang, Jing,

Zhang, Yuan,

Chua, Melvin L. K,

Ma, Jun,

Lv, Jia-Wei,

Tang, Ling-Long

2019

Overview

Adding three cycles of induction chemotherapy with gemcitabine and cisplatin to concurrent chemoradiotherapy improved 3-year recurrence-free survival (85.3%, vs. 76.5% with concurrent chemoradiotherapy alone) and overall survival (94.6% vs. 90.3%). Patients receiving induction chemotherapy were more likely to have grade 3 or 4 myelosuppression, nausea, and vomiting.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adult

/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use