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Safety assessment of leaf curl virus resistant tomato developed using viral derived sequences
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Safety assessment of leaf curl virus resistant tomato developed using viral derived sequences
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Journal Article
Safety assessment of leaf curl virus resistant tomato developed using viral derived sequences
2009
Overview
Genetic engineering of food crops has significantly influenced the agricultural productivity over the past two decades. It has proved a valuable tool, offering crops with higher yields, improved nutritional quality, resistance against pesticides, herbicides and tolerance against abiotic stresses. However, the safety assessment of genetically engineered (GE) crops is prerequisite before introduction into human food chain. The present study was aimed to assess the toxicity and allergenicity of leaf curl virus resistant GE tomato compared to its wild-type species. Balb/c mice fed with genetically engineered or wild-type tomato did not show significant differences in growth, body weight (P > 0.05) and food consumption when compared with control mice. Values for serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase, urea and cholesterol were comparable in GE and wild-type tomato fed mice. Mice immunized with GE or wild-type tomato extract showed low IgE response. Lung histology of ovalbumin fed mice showed bronchoconstriction with eosinophilic infiltration whereas GE or wild-type tomato showed no cellular infiltration with normal airways. Genetically engineered and wild-type tomato sensitized mice demonstrated similar IL-4 release in splenic cell culture supernatant. GE and wild tomato extract on ELISA showed comparable IgE binding (P > 0.05) with food allergic patients' sera. In conclusion, genetically engineered tomato showed no toxicity in mice and allergenicity is similar to the wild-type tomato.
Publisher
Dordrecht : Springer Netherlands,Springer Netherlands,Springer,Springer Nature B.V
Subject
/ Animal Genetics and Genomics
/ Animals
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ blood
/ Crops
/ Enzyme-linked immunosorbent assay
/ Food Hypersensitivity - blood
/ foods
/ Fundamental and applied biological sciences. Psychology
/ genetics
/ Humans
/ Immunoglobulin E - immunology
/ Leaves
/ Lung
/ Lycopersicon esculentum - adverse effects
/ Lycopersicon esculentum - genetics
/ Lycopersicon esculentum - immunology
/ Methods. Procedures. Technologies
/ Mice
/ patients
/ Plants, Genetically Modified
/ Plants, Genetically Modified - adverse effects
/ Plants, Genetically Modified - genetics
/ Serum
/ Spleen
/ Stress
/ tomatoes
/ Toxicity
/ Transgenic animals and transgenic plants
/ Urea
/ viruses
