Journal Article

Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut

Popovic, Ana, Bourdon, Celine, Bandsma, Robert H. J., Parkinson, John, Wang, Pauline W., Soofi, Sajid, Guttman, David S., Pell, Lisa G., Bhutta, Zulfiqar A.

2021

Overview

Supplementation with micronutrients, including vitamins, iron and zinc, is a key strategy to alleviate child malnutrition. However, association of gastrointestinal disorders with iron has led to ongoing debate over their administration. To better understand their impact on gut microbiota, we analyse the bacterial, protozoal, fungal and helminth communities of stool samples collected from a subset of 80 children at 12 and 24 months of age, previously enrolled into a large cluster randomized controlled trial of micronutrient supplementation in Pakistan (ClinicalTrials.gov identifier NCT00705445). We show that while bacterial diversity is reduced in supplemented children, vitamins and iron (as well as residence in a rural setting) may promote colonization with distinct protozoa and mucormycetes, whereas the addition of zinc appears to ameliorate this effect. We suggest that the risks and benefits of micronutrient interventions may depend on eukaryotic communities, potentially exacerbated by exposure to a rural setting. Larger studies are needed to evaluate the clinical significance of these findings and their impact on health outcomes. Micronutrient supplements are key to global efforts to address child malnutrition. Here, in a cohort of children, previously enrolled into a large cluster randomized controlled trial of micronutrient supplementation in Pakistan, Popovic et al . find that vitamins and iron increase carriage of protozoa and fungi in the gut, potentially disrupting the bacterial microbiome.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 45/22 / 45/23 / 45/77 / 631/326/2565/2134 / 631/326/417 / Animals / Bacteria / Bacteria - classification / Bacteria - drug effects / Bacteria - genetics / Child, Preschool / Children / Clinical trials / Clusters / Dietary Supplements / Digestive system / Female / Fungi / Fungi - classification / Fungi - drug effects / Fungi - genetics / Gastrointestinal diseases / Gastrointestinal tract / Humanities and Social Sciences / Humans / Infant / Intestinal microflora / Intestines - drug effects / Intestines - microbiology / Intestines - parasitology / Iron / Iron - administration & dosage / Male / Malnutrition / Microbiomes / Microbiota / Micronutrients / Micronutrients - administration & dosage / multidisciplinary / Mycobiome - drug effects / Mycobiome - genetics / Parasites - classification / Parasites - drug effects / Parasites - genetics / Phylogeny / Physical growth / Prospective Studies / Protozoa / Science / Science (multidisciplinary) / Supplements / Vitamins / Vitamins - administration & dosage / Zinc / Zinc - administration & dosage