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The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis
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The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis
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Journal Article
The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis
2025
Overview
Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, with metastatic CRC (mCRC) posing significant challenges due to tumor heterogeneity and resistance to therapy. Circulating tumor cells (CTC) and circulating hybrid cells (CHC) detected via liquid biopsies have emerged as promising biomarkers for monitoring disease progression. This study aimed to evaluate the prognostic utility of automated CTC enumeration using the ACCEPT software compared to a manual method and assess the potential clinical relevance of CHC in mCRC. A retrospective analysis of CellSearch® images from 67 mCRC patients was conducted, correlating CTC and CHC counts with progression‐free survival and overall survival (OS). Automated enumeration demonstrated improved accuracy and reduced variability, confirming the prognostic significance of CTC counts for OS. However, CHC enumeration showed no significant association with clinical outcomes, suggesting sporadic detection rather than consistent prognostic value. These findings underscore the reliability of automated CTC enumeration in mCRC prognosis while highlighting the need for further research into the biological and clinical roles of CHC. This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach. Findings emphasize the need for improved reliability and standardization in CTC detection methods for mCRC management.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
/ Adult
/ Aged
/ Biopsy
/ Cancer
/ circulating hybrid cells (CHC)
/ circulating tumor cells (CTC)
/ Colorectal Neoplasms - blood
/ Colorectal Neoplasms - diagnosis
/ Colorectal Neoplasms - mortality
/ Colorectal Neoplasms - pathology
/ Female
/ Humans
/ Male
/ metastatic colorectal cancer (mCRC)
/ Neoplastic Cells, Circulating - pathology
/ Oncology
/ Patients
/ Tumors
