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Ground-truth encoding of self-motion in the primate cerebellar nodulus and uvula
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Ground-truth encoding of self-motion in the primate cerebellar nodulus and uvula
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Journal Article
Ground-truth encoding of self-motion in the primate cerebellar nodulus and uvula
2026
Overview
Accurate internal estimates of self-motion and orientation relative to gravity are fundamental for stabilizing gaze, controlling posture, and navigating through dynamic environments. Prevailing theories propose that the cerebellar nodulus and uvula (NU) employ internal models to suppress sensory input arising from predictable, self-generated motion. However, this assumption has never been directly tested. Here, we recorded NU Purkinje cell activity in rhesus monkeys during active and passive head movements. We found neurons responsive to passive translations remained equally sensitive to self-generated movements, encoding net head motion in space irrespective of its source. Furthermore, external perturbation did not influence these ground-truth encoding. When active head motion was blocked, Purkinje cell activity remained unchanged – demonstrating a lack of efference copy integration. During active tilts, NU neurons encoded both dynamic motion and static orientation relative to gravity. These findings challenge the internal model hypothesis and establish the NU as a ground-truth, context-invariant estimator of self-motion, supporting stable behavior in dynamic environments.
How the brain meets these competing demands–and where such a veridical “ground-truth” representation is computed–remains unknown. Here authors show that the cerebellar nodulus/uvula–a region essential for postural control–provides a stable, ground-truth representation of self-motion during voluntary movement, rather than suppressing self-generated signals.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 64
/ 9/97
/ Animals
/ Coding
/ Humanities and Social Sciences
/ Male
/ Motion
/ Motion Perception - physiology
/ Neurons
/ Science
