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Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism
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Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism
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Journal Article
Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism
2025
Overview
Age-related macular degeneration (AMD) is a leading cause of blindness in people over 50. AMD and cardiovascular disease share risk factors including age, impaired lipid metabolism, and extracellular lipid deposition. Because of its importance in age-related diseases, we hypothesize that apolipoprotein M (ApoM), a lipocalin that binds sphingosine-1-phosphate (S1P), might restore lipid homeostasis and retinal function in AMD. In support, we find that human patients with AMD demonstrate significantly reduced ApoM compared to controls. In mice with impaired retinal cholesterol efflux, ApoM improves retinal pigment epithelium (RPE) function and lipotoxicity in an S1P- and S1P receptor 3-dependent manner. Ultrastructural evidence of enhanced melanosome-lipid droplet interactions led us to hypothesize and demonstrate that ApoM-S1P signaling drives RPE-specific lysosomal lipid catabolism. RPE-specific knockout of lysosomal acid lipase recapitulates features of AMD. Our study defines a novel role for ApoM/S1P signaling in AMD driven by RPE lipotoxicity, mediated by cell-autonomous lysosomal lipid catabolism.
Age-related macular degeneration (AMD) is a leading cause of blindness. Here, the authors identify a role for apolipoprotein M in AMD that may present a therapeutic target.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
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/ 59
/ 64
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/ 82/51
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/ 96
/ Age
/ Aged
/ Animals
/ Apolipoproteins M - genetics
/ Apolipoproteins M - metabolism
/ Efflux
/ Female
/ Humanities and Social Sciences
/ Humans
/ Lipids
/ Lysophospholipids - metabolism
/ Macular Degeneration - genetics
/ Macular Degeneration - metabolism
/ Macular Degeneration - pathology
/ Male
/ Mice
/ Plasma
/ Retina
/ Retinal Pigment Epithelium - metabolism
/ Retinal Pigment Epithelium - pathology
/ Science
