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Longitudinal assessment of renal allograft function in donors and pediatric recipients by arterial spin labeling MRI perfusion quantification
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Longitudinal assessment of renal allograft function in donors and pediatric recipients by arterial spin labeling MRI perfusion quantification
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Journal Article
Longitudinal assessment of renal allograft function in donors and pediatric recipients by arterial spin labeling MRI perfusion quantification
2025
Overview
We analyzed cortical renal blood flow (cRBF) by ASL-MRI in ten donors (4 females, mean age 46 ± 6) and dedicated pediatric recipients (4 females, mean age 14 ± 4) before transplantation and at 3-, 6-, and 12-months post-transplant to identify allograft functional adaptation. Baseline values were compared to post-transplant values and correlated with estimated glomerular filtration rate (eGFR). Additionally, renal plasma flow (RPF) and estimated filtration fraction (eFF) were calculated. Both cRBF and eGFR demonstrated a highly significant increase at 3 months compared to baseline (mean cRBF 251.71 ± 78.27 vs. 486.61 ± 156.08 ml/kidney/min,
p
= 0.0001; mean eGFR 46.62 ± 16.36 vs. 69.81 ± 24.83 ml/min/1.73 m
2
;
p
= 0.02) and remained consistent until the end of the observed period. Patients with impaired function and lower eGFR at 3 months exhibited a smaller increase in cRBF compared to the rest of the group (
p
= 0.01). eFF did not change significantly throughout the observed period (
p
= 0.07,
p
= 0.07, and
p
= 0.68, respectively), suggesting absence of hyperfiltration. cRBF may serve as a significant renal biomarker for longitudinal follow-up of renal allografts, enabling tracking of perfusion adaptation and identification of critical timepoints for clinical intervention.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
