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PD-1/PD-L1 pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats
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PD-1/PD-L1 pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats
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PD-1/PD-L1 pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats
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Journal Article
PD-1/PD-L1 pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats
2025
Overview
Acute postoperative pain represents a significant clinical challenge, yet its underlying mechanisms remain incompletely understood. A previous study found that PD-1/PD-L1can relieve chronic pain. Mechanical withdrawal thresholds (MWT) and thermal withdrawal latency (TWL) were quantified in rats at baseline (pre-incision) and at postoperative timepoints of 2, 8, and 24 h. Concurrently, PD-1/PD-L1 expression levels and neuroinflammatory markers were assessed at the 24-hour terminal timepoint. PD-1 inhibitors and agonists were administered via intrathecal injection immediately after surgical incision and at 12 h postoperatively, respectively. It was found that incision surgery resulted in significant postoperative pain accompanied by upregulation of PD-1/PD-L1 and neuroinflammation. Inhibition of PD-1 expression could further exacerbate acute postoperative pain by upregulating neuroinflammation, whereas upregulation of PD-1 expression could alleviate acute postoperative pain by inhibiting neuroinflammation. Activation of the PD-1/PD-L1 pathway relieves acute postoperative pain induced by plantar incision. This may be a therapeutic target for acute postoperative pain.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/337
/ 631/80
/ Animals
/ Enzymes
/ Ganglia, Spinal - metabolism
/ Humanities and Social Sciences
/ Latency
/ Ligands
/ Male
/ Neuroinflammatory Diseases - metabolism
/ Pain
/ PD-1
/ PD-L1
/ Postoperative Pain - drug therapy
/ Postoperative Pain - etiology
/ Postoperative Pain - metabolism
/ Programmed Cell Death 1 Receptor - antagonists & inhibitors
/ Programmed Cell Death 1 Receptor - metabolism
/ Proteins
/ Rats
/ Science
/ Surgery
