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Augmenting phage therapy using green nanotechnology for promising infection control, wound healing and devoiding phage resistance in MDR Pseudomonas aeruginosa
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Augmenting phage therapy using green nanotechnology for promising infection control, wound healing and devoiding phage resistance in MDR Pseudomonas aeruginosa
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Journal Article
Augmenting phage therapy using green nanotechnology for promising infection control, wound healing and devoiding phage resistance in MDR Pseudomonas aeruginosa
2025
Overview
Humanity could descend into a pre-antibiotic world as a result of antimicrobial resistance (AMR). Phage defenses are considered “vintage heroes” in the battle against multidrug-resistant (MDR) bacteria. However, phage resistance continues to evolve, necessitating alternative strategies. A potential solution is combining phages with antimicrobials like silver nanoparticles (AgNPs) to enhance the phage therapy. This study focuses on a combination therapy using
Bauhinia variegata L.
-mediated AgNPs and
Pseudomonas
phage M12PA to target multidrug-resistant (MDR)
Pseudomonas aeruginosa
. The antibacterial properties of this combination were evaluated through comprehensive characterizations and assays. As a proof of concept, the AgNP-phage combination delayed phage resistance by 6–12 h, reduced mutation, and enhanced antibacterial efficiency. Anti-biofilm activity improved by ~ 40% compared to AgNPs alone at sub-inhibitory concentrations. AgNPs and phages have demonstrated excellent compatibility, and the phage titer did not drop noticeably over 30 days. Biocompatibility assessments, including cell viability and hemolysis assays, highlighted the safety of biosynthesized AgNPs. Wound healing efficacy was also demonstrated in mouse fibroblast cells and an
in ovo
angiogenesis model. This study underscores the efficiency of phage-AgNPs synergy to be a potential therapeutic approach for MDR bacterial wound infection, showing effective anti-biofilm activity, delayed phage resistance, and minimal toxicity.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/326
/ 639/301
/ 639/925
/ Animals
/ Anti-Bacterial Agents - pharmacology
/ Biofilms
/ Drug Resistance, Multiple, Bacterial
/ Humanities and Social Sciences
/ Humans
/ Metal Nanoparticles - chemistry
/ Mice
/ Phages
/ Pseudomonas aeruginosa - drug effects
/ Pseudomonas aeruginosa - physiology
/ Pseudomonas aeruginosa - virology
/ Pseudomonas Infections - microbiology
/ Pseudomonas Infections - therapy
/ Pseudomonas Phages - physiology
/ Science
/ Silver
/ Toxicity
