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Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

by Monticelli, Laurel A. , Nice, Timothy J. , Osborne, Lisa C. , Boucher, Jean-Luc , Bailey, Aubrey G. , Bittinger, Kyle , Kobuley, Dmytro , Allen, Judith E. , Tran, Sara V. , Wherry, E. John , Virgin, Herbert W. , Laughlin, Alice L. , Hepworth, Matthew R. , Tomov, Vesselin T. , Artis, David , Sutherland, Tara E. , Siracusa, Mark C. , Bushman, Frederic D.

in Antivirals / Coinfection / Containment / Flavours / Helminthiasis / helminths / Immune response / Immune system / Immune systems / Immunity / Immunology / Immunomodulation / Infections / Macrophages / Mice / Microbiology / Microbiota / mixed infection / Neutralization / Parasites / Parasitology / Pathogens / Spleen / T lymphocytes / Virology / Viruses / Worms

2014

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Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

2014

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Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

2014

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Journal Article

Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

Monticelli, Laurel A.,

Nice, Timothy J.,

Osborne, Lisa C.,

Boucher, Jean-Luc,

Bailey, Aubrey G.,

Bittinger, Kyle,

Kobuley, Dmytro,

Allen, Judith E.,

Tran, Sara V.,

Wherry, E. John,

Virgin, Herbert W.,

Laughlin, Alice L.,

Hepworth, Matthew R.,

Tomov, Vesselin T.,

Artis, David,

Sutherland, Tara E.,

Siracusa, Mark C.,

Bushman, Frederic D.

2014

Overview

The mammalian intestine is colonized by beneficial commensal bacteria and is a site of infection by pathogens, including helminth parasites. Helminths induce potent immunomodulatory effects, but whether these effects are mediated by direct regulation of host immunity or indirectly through eliciting changes in the microbiota is unknown. We tested this in the context of virus-helminth coinfection. Helminth coinfection resulted in impaired antiviral immunity and was associated with changes in the microbiota and STAT6-dependent helminth-induced alternative activation of macrophages. Notably, helminth-induced impairment of antiviral immunity was evident in germ-free mice, but neutralization of Ym1, a chitinase-like molecule that is associated with alternatively activated macrophages, could partially restore antiviral immunity. These data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1.

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American Association for the Advancement of Science,The American Association for the Advancement of Science

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