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Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation
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Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation
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Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation
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Journal Article
Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation
2015
Overview
The innate immune system is the first line of defense against viral infections. Exploiting innate responses for antiviral, therapeutic and vaccine adjuvation strategies is being extensively explored. We have previously described, the ability of small in vitro RNA transcripts, mimicking the sequence and structure of different domains in the non-coding regions of the foot-and-mouth disease virus (FMDV) genome (ncRNAs), to trigger a potent and rapid innate immune response. These synthetic non-infectious molecules have proved to have a broad-range antiviral activity and to enhance the immunogenicity of an FMD inactivated vaccine in mice. Here, we have studied the involvement of pattern-recognition receptors (PRRs) in the ncRNA-induced innate response and analyzed the antiviral and cytokine profiles elicited in swine cultured cells, as well as peripheral blood mononuclear cells (PBMCs).
Publisher
MDPI AG,MDPI
Subject
/ Antibodies, Viral - immunology
/ DEAD-box RNA Helicases - genetics
/ DEAD-box RNA Helicases - immunology
/ Female
/ Foot-and-Mouth Disease - genetics
/ Foot-and-Mouth Disease - immunology
/ Foot-and-Mouth Disease - prevention & control
/ Foot-and-Mouth Disease - virology
/ Foot-and-mouth disease virus
/ Foot-and-Mouth Disease Virus - genetics
/ Foot-and-Mouth Disease Virus - immunology
/ Genomes
/ Leukocytes, Mononuclear - immunology
/ Ligands
/ Male
/ Mice
/ RNA, Viral - administration & dosage
/ RNA, Viral - chemical synthesis
/ Sensors
/ Swine
/ Toll-Like Receptors - genetics
/ Toll-Like Receptors - immunology
/ Vaccines
/ Viral Vaccines - administration & dosage
/ Viral Vaccines - chemical synthesis
/ Viruses
