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Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea

by Wang, Dinghao , Yuan, Jingxue , Xiong, Zhihao , Song, Yue , Ni, Jinxia , Zhang, Ziniu

in Abdomen / Acupuncture / Analgesics / Animals / Antibodies / Biotechnology / Coagulation / Cold / Cold Temperature / Contraceptives / COX-2/mPGES-1/PGE2 pathway / Cyclooxygenase 2 - metabolism / Dinoprostone - metabolism / Disease Models, Animal / dysmenorrhea / Dysmenorrhea - etiology / Dysmenorrhea - metabolism / Dysmenorrhea - therapy / Electroacupuncture / Electroacupuncture - methods / Endorphins / Female / high-frequency electroacupuncture / Hormones / Immunology / Inflammation / Intervention / Low back pain / low-frequency electroacupuncture / Medical equipment / Menstruation / Nonsteroidal anti-inflammatory drugs / Pain / Prostaglandin E2 / Prostaglandin-E synthase / Rats / Rats, Sprague-Dawley / Signal Transduction / β-EP

2025

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Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea

by Wang, Dinghao , Yuan, Jingxue , Xiong, Zhihao , Song, Yue , Ni, Jinxia , Zhang, Ziniu

2025

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Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea

by Wang, Dinghao , Yuan, Jingxue , Xiong, Zhihao , Song, Yue , Ni, Jinxia , Zhang, Ziniu

2025

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Journal Article

Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea

Wang, Dinghao,

Yuan, Jingxue,

Xiong, Zhihao,

Song, Yue,

Ni, Jinxia,

Zhang, Ziniu

2025

Overview

Primary dysmenorrhea (PD) refers to a condition in which women experience cyclic lower abdominal pain, often accompanied by lower back pain, and even severe pain and fainting around menstruation, significantly affecting daily activities and work. Inflammatory factors such as prostaglandins PGF2α, PGE2, and COX-2 play key roles in the pathological mechanisms of PD. Nonsteroidal anti-inflammatory drugs (NSAIDs) and hormonal contraceptives are the first-line treatments for dysmenorrhea; however, they have significant side effects. Electroacupuncture, as a non-invasive and effective therapeutic method, is widely used as a complementary and alternative treatment, although its mechanism of action remains unclear.

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Publisher

Frontiers Media SA,Frontiers Media S.A

Subject

/ Animals