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Bile acids induce hepatic differentiation of mesenchymal stem cells
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Bile acids induce hepatic differentiation of mesenchymal stem cells
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Journal Article
Bile acids induce hepatic differentiation of mesenchymal stem cells
2015
Overview
Mesenchymal stem cells (MSC) have the potential to differentiate into multiple cell lineages and their therapeutic potential has become obvious. In the liver, MSC are represented by stellate cells which have the potential to differentiate into hepatocytes after stimulation with growth factors. Since bile acids can promote liver regeneration, their influence on liver-resident and bone marrow-derived MSC was investigated. Physiological concentrations of bile acids such as tauroursodeoxycholic acid were able to initiate hepatic differentiation of MSC via the farnesoid X receptor and transmembrane G-protein-coupled bile acid receptor 5 as investigated with knockout mice. Notch, hedgehog, transforming growth factor-β/bone morphogenic protein family and non-canonical Wnt signalling were also essential for bile acid-mediated differentiation, whereas β-catenin-dependent Wnt signalling was able to attenuate this process. Our findings reveal bile acid-mediated signalling as an alternative way to induce hepatic differentiaion of stem cells and highlight bile acids as important signalling molecules during liver regeneration.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Acids
/ Animals
/ Bile
/ Bile Acids and Salts - metabolism
/ Cell Differentiation - physiology
/ Hepatic Stellate Cells - cytology
/ Hepatic Stellate Cells - physiology
/ Humanities and Social Sciences
/ Liver
/ Mesenchymal Stromal Cells - cytology
/ Mesenchymal Stromal Cells - physiology
/ Mice
/ Rats
/ Rodents
/ Science
