Asset Details
Do you wish to reserve the book?
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors
Do you wish to request the book?
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors
2014
Overview
Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. Recently, common dysfunctional variants of
ABCG2
, a urate exporter gene also known as
BCRP
, are revealed to be a major cause of gout/hyperuricemia. Here, we compared the influence of ABCG2 dysfunction on serum uric acid (SUA) levels with other typical risk factors in a cohort of 5,005 Japanese participants. ABCG2 dysfunction was observed in 53.3% of the population investigated and its population-attributable risk percent (PAR%) for hyperuricemia was 29.2%, much higher than those of the other typical environmental risks, i.e. overweight/obesity (BMI ≥ 25.0; PAR% = 18.7%), heavy drinking (>196 g/week (male) or >98 g/week (female) of pure alcohol; PAR% = 15.4%) and aging (≥60 years old; PAR% = 5.74%). SUA significantly increased as the ABCG2 function decreased (P = 5.99 × 10
−19
). A regression analysis revealed that ABCG2 dysfunction had a stronger effect than other factors; a 25% decrease in ABCG2 function was equivalent to “an increase of BMI by 1.97-point” or “552.1 g/week alcohol intake as pure ethanol” in terms of ability to increase SUA. Therefore, ABCG2 dysfunction originating from common genetic variants has a much stronger impact on the progression of hyperuricemia than other familiar risks. Our study provides a better understanding of common genetic factors for common diseases.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 692/499
/ Alcohol
/ Asian Continental Ancestry Group - genetics
/ ATP Binding Cassette Transporter, Sub-Family G, Member 2
/ ATP-Binding Cassette Transporters - genetics
/ Ethanol
/ Female
/ Genetic Predisposition to Disease - genetics
/ Genetic Variation - genetics
/ Gout
/ Humanities and Social Sciences
/ Humans
/ Male
/ Neoplasm Proteins - genetics
/ Science
