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Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community
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Journal Article
Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community
2015
Overview
Probiotics are well known as health-promoting agents that modulate intestinal microbiota. However, the molecular mechanisms underlying this effect remain unclear. Using gnotobiotic mice harboring 15 strains of predominant human gut-derived microbiota (HGM), we investigated the effects of
Bifidobacterium longum
BB536 (BB536-HGM) supplementation on the gut luminal metabolism. Nuclear magnetic resonance (NMR)-based metabolomics showed significantly increased fecal levels of pimelate, a precursor of biotin and butyrate in the BB536-HGM group. In addition, the bioassay revealed significantly elevated fecal levels of biotin in the BB536-HGM group. Metatranscriptomic analysis of fecal microbiota followed by an
in vitro
bioassay indicated that the elevated biotin level was due to an alteration in metabolism related to biotin synthesis by
Bacteroides caccae
in this mouse model. Furthermore, the proportion of
Eubacterium rectale
, a butyrate producer, was significantly higher in the BB536-HGM group than in the group without
B. longum
BB536 supplementation. Our findings help to elucidate the molecular basis underlying the effect of
B. longum
BB536 on the gut luminal metabolism through its interactions with the microbial community.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Bifidobacterium - drug effects
/ Bifidobacterium - metabolism
/ Biotin
/ Feces
/ Gastrointestinal Tract - drug effects
/ Gastrointestinal Tract - microbiology
/ Gene Expression Regulation - drug effects
/ Humanities and Social Sciences
/ Humans
/ Magnetic Resonance Spectroscopy
/ Mice
/ NMR
/ Science
/ Water
/ Yogurt
