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Local bacteria affect the efficacy of chemotherapeutic drugs
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Journal Article
Local bacteria affect the efficacy of chemotherapeutic drugs
2015
Overview
In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and cancer cell lines were examined
in vitro
and
in vivo
for changes in the efficacy of cancer cell killing mediated by chemotherapeutic agents. Of 30 drugs examined
in vitro
, the efficacy of 10 was found to be significantly inhibited by certain bacteria, while the same bacteria improved the efficacy of six others. HPLC and mass spectrometry analyses of sample drugs (gemcitabine, fludarabine, cladribine, CB1954) demonstrated modification of drug chemical structure. The chemoresistance or increased cytotoxicity observed
in vitro
with sample drugs (gemcitabine and CB1954) was replicated in
in vivo
murine subcutaneous tumour models. These findings suggest that bacterial presence in the body due to systemic or local infection may influence tumour responses or off-target toxicity during chemotherapy.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/106
/ 59
/ 59/5
/ 64
/ Animals
/ Antineoplastic Agents - pharmacokinetics
/ Antineoplastic Agents - pharmacology
/ Aziridines - pharmacokinetics
/ Bacteria
/ Cancer
/ Cladribine - pharmacokinetics
/ Colonic Neoplasms - drug therapy
/ Colonic Neoplasms - metabolism
/ Colonic Neoplasms - microbiology
/ Colonic Neoplasms - pathology
/ Deoxycytidine - analogs & derivatives
/ Deoxycytidine - pharmacokinetics
/ Deoxycytidine - pharmacology
/ Drugs
/ Escherichia coli - growth & development
/ Female
/ High-performance liquid chromatography
/ Humanities and Social Sciences
/ Listeria - growth & development
/ Mice
/ Science
/ Toxicity
/ Tumors
/ Vidarabine - analogs & derivatives
