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DNA methylation signatures link prenatal famine exposure to growth and metabolism
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Journal Article
DNA methylation signatures link prenatal famine exposure to growth and metabolism
2014
Overview
Periconceptional diet may persistently influence DNA methylation levels with phenotypic consequences. However, a comprehensive assessment of the characteristics of prenatal malnutrition-associated differentially methylated regions (P-DMRs) is lacking in humans. Here we report on a genome-scale analysis of differential DNA methylation in whole blood after periconceptional exposure to famine during the Dutch Hunger Winter. We show that P-DMRs preferentially occur at regulatory regions, are characterized by intermediate levels of DNA methylation and map to genes enriched for differential expression during early development. Validation and further exploratory analysis of six P-DMRs highlight the critical role of gestational timing. Interestingly, differential methylation of the P-DMRs extends along pathways related to growth and metabolism. P-DMRs located in
INSR
and
CPT1A
have enhancer activity
in vitro
and differential methylation is associated with birth weight and serum LDL cholesterol. Epigenetic modulation of pathways by prenatal malnutrition may promote an adverse metabolic phenotype in later life.
The long-term effect of prenatal nutrition on gene regulation is largely unknown. Here the authors identify differentially methylated regions in whole blood from individuals exposed to famine early after conception, and show that these epigenetic changes may have adverse metabolic consequences later in life.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group
Subject
/ Carnitine O-Palmitoyltransferase - genetics
/ Carnitine O-Palmitoyltransferase - metabolism
/ DNA
/ Famine
/ Female
/ Fetal Nutrition Disorders - genetics
/ Fetal Nutrition Disorders - metabolism
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Hunger
/ Male
/ Prenatal Exposure Delayed Effects - genetics
/ Prenatal Exposure Delayed Effects - metabolism
/ Receptor, Insulin - genetics
/ Receptor, Insulin - metabolism
/ Science
/ Siblings
