Asset Details
Do you wish to reserve the book?
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity
Do you wish to request the book?
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity
2021
Overview
Tissue-resident memory T (T
RM
) cells are non-recirculating cells that exist throughout the body. Although T
RM
cells in various organs rely on common transcriptional networks to establish tissue residency, location-specific factors adapt these cells to their tissue of lodgment. Here we analyze T
RM
cell heterogeneity between organs and find that the different environments in which these cells differentiate dictate T
RM
cell function, durability and malleability. We find that unequal responsiveness to TGFβ is a major driver of this diversity. Notably, dampened TGFβ signaling results in CD103
−
T
RM
cells with increased proliferative potential, enhanced function and reduced longevity compared with their TGFβ-responsive CD103
+
T
RM
counterparts. Furthermore, whereas CD103
−
T
RM
cells readily modified their phenotype upon relocation, CD103
+
T
RM
cells were comparatively resistant to transdifferentiation. Thus, despite common requirements for T
RM
cell development, tissue adaptation of these cells confers discrete functional properties such that T
RM
cells exist along a spectrum of differentiation potential that is governed by their local tissue microenvironment.
Tissue-resident memory T (T
RM
) cells are distributed throughout the body as relatively sessile populations. Mackay and colleagues find that the tissue in which T
RM
cells are generated dictates their properties and is in turn defined according to T
RM
-cell-intrinsic sensitivity to signaling via the cytokine TGFβ.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ CD8-Positive T-Lymphocytes - cytology
/ CD8-Positive T-Lymphocytes - immunology
/ Cell Differentiation - immunology
/ Cell Plasticity - immunology
/ Cellular Microenvironment - immunology
/ Female
/ Immunologic Memory - immunology
/ Integrin alpha Chains - immunology
/ Liver
/ Mice
/ Signal Transduction - immunology
/ Skin
/ T cells
/ Tissues
