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Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children

by Coelho, Alexandra , Ali, Shabinah , Ngampiyaskul, Chaiwat , Kityo, Cissy M , Colbers, Angela , Bbuye, Dickson , Cressey, Tim R , Rojo, Pablo , Giaquinto, Carlo , Saïdi, Yacine , Amuge, Pauline , Liberty, Afaaf , Atwine, Lorna , Mujuru, Hilda A , Cotton, Mark F , Kobbe, Robin , Turkova, Anna , Ford, Deborah , Violari, Avy , Shakeshaft, Clare , Compagnucci, Alexandra , Ahimbisibwe, Grace M , Gibb, Diana M , Kaudha, Elizabeth , Archary, Moherndran , Grossele, Tiziana , Wynne, Ben , Musiime, Victor , Welch, Steven B , Musoro, Godfrey , Klein, Nigel , Lugemwa, Abbas , Ramsagar, Nastassja , Behuhuma, Osee , Bwakura-Dangarembizi, Mutsa , Makumbi, Shafic , Sarfati, Tatiana , Kekitiinwa, Adeodata R , Puthanakit, Thanyawee , Musoke, Philippa , Chalermpantmetagul, Suwalai , Barlow-Mosha, Linda , Variava, Ebrahim , Bernays, Sarah , White, Ellen

in Acquired immune deficiency syndrome / Administration, Oral / Adolescence / Adolescent / Adolescents / Adverse events / AIDS / Alkynes - therapeutic use / Anti-Retroviral Agents - adverse effects / Anti-Retroviral Agents - therapeutic use / Antiretroviral drugs / Antiretroviral therapy / Benzoxazines - therapeutic use / Caregivers / Child / Child, Preschool / Children / Cholesterol - blood / Cyclopropanes - therapeutic use / Drug Therapy, Combination / Efavirenz / FDA approval / Female / Global Health / Heterocyclic Compounds, 3-Ring - administration & dosage / Heterocyclic Compounds, 3-Ring - adverse effects / Heterocyclic Compounds, 3-Ring - therapeutic use / HIV / HIV Infections - drug therapy / HIV Infections - virology / HIV Integrase Inhibitors - administration & dosage / HIV Integrase Inhibitors - adverse effects / HIV Integrase Inhibitors - therapeutic use / HIV Protease Inhibitors - therapeutic use / HIV-1 - isolation & purification / Human immunodeficiency virus / Humans / Immune system / Infections / Infectious Disease / Integrase / Life Sciences / Male / Mutation / Oxazines - administration & dosage / Oxazines - adverse effects / Oxazines - therapeutic use / Pediatrics / Pediatrics General / Piperazines - administration & dosage / Piperazines - adverse effects / Piperazines - therapeutic use / Proteinase inhibitors / Pyridones - administration & dosage / Pyridones - adverse effects / Pyridones - therapeutic use / Santé publique et épidémiologie / Teenagers / Viral Load - drug effects

2021

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Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children

2021

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Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children

2021

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Journal Article

Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children

Coelho, Alexandra,

Ali, Shabinah,

Ngampiyaskul, Chaiwat,

Kityo, Cissy M,

Colbers, Angela,

Bbuye, Dickson,

Cressey, Tim R,

Rojo, Pablo,

Giaquinto, Carlo,

Saïdi, Yacine,

Amuge, Pauline,

Liberty, Afaaf,

Atwine, Lorna,

Mujuru, Hilda A,

Cotton, Mark F,

Kobbe, Robin,

Turkova, Anna,

Ford, Deborah,

Violari, Avy,

Shakeshaft, Clare,

Compagnucci, Alexandra,

Ahimbisibwe, Grace M,

Gibb, Diana M,

Kaudha, Elizabeth,

Archary, Moherndran,

Grossele, Tiziana,

Wynne, Ben,

Musiime, Victor,

Welch, Steven B,

Musoro, Godfrey,

Klein, Nigel,

Lugemwa, Abbas,

Ramsagar, Nastassja,

Behuhuma, Osee,

Bwakura-Dangarembizi, Mutsa,

Makumbi, Shafic,

Sarfati, Tatiana,

Kekitiinwa, Adeodata R,

Puthanakit, Thanyawee,

Musoke, Philippa,

Chalermpantmetagul, Suwalai,

Barlow-Mosha, Linda,

Variava, Ebrahim,

Bernays, Sarah,

White, Ellen

2021

Overview

In an open-label, randomized, noninferiority trial, dolutegravir-based antiretroviral therapy was compared with standard care in children and adolescents starting first- or second-line therapy for HIV type 1 infection. Dolutegravir-based ART was superior to standard-care ART.

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Publisher

Massachusetts Medical Society

Subject

Acquired immune deficiency syndrome

/ Administration, Oral

/ AIDS