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In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers
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In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers
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Journal Article
In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers
2017
Overview
Non-invasive monitoring of gastrointestinal drug release
in vivo
is extremely challenging because of the limited spatial resolution and long scanning time of existing bioimaging modalities, such as X-ray radiation and magnetic resonance. Here, we report a novel microcarrier that can retain drugs and withstand the harsh conditions of gastrointestinal tract. Significantly, we can track the microcarrier fate and semi-quantitatively monitor the content of drug released
in vivo
in real time by measuring the fluorescence signals in the second near-infrared window of lanthanide-based downconversion nanoparticles with an absorption competition-induced emission bioimaging system. The microcarriers show a prolonged residence time of up to 72 h in the gastrointestinal tract, releasing up to 62% of their content. Moreover, minimal deposition of the microcarriers is found in non-target organs, such as the liver, spleen and kidney. These findings provide novel insights for the development of therapeutic and bioimaging strategies of orally administered drugs.
The sustained release of drugs within the gastrointestinal tract as well as their detection following administration is a challenge. Here, the authors develop a microcarrier that supported sustained drug release in the gastrointestinal tract
in vivo
and could be monitored with real-time imaging.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Animals
/ Biomimetic Materials - chemistry
/ Drug Carriers - chemical synthesis
/ Drug Carriers - pharmacokinetics
/ Drugs
/ Female
/ Humanities and Social Sciences
/ Intestinal Mucosa - metabolism
/ Intestines - diagnostic imaging
/ Mice
/ Optical Imaging - instrumentation
/ Phosphatidylethanolamines - chemistry
/ Polyethylene Glycols - chemistry
/ Proteins
/ Science
/ Spectroscopy, Near-Infrared - instrumentation
/ Spectroscopy, Near-Infrared - methods
